Inflammation and Alzheimer's disease: Possible role of periodontal diseases

Kamer, Angela R.; Craig, Ronald G.; Dasanayake, Ananda P.; Bryś, Mirosław; Głodzik-Sobańska, Lidia; Leon, Mony J. de

doi:10.1016/j.jalz.2007.08.004

Cited by 319 publications

(304 citation statements)

References 47 publications

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“…Kamer et al have proposed that periodontal disease induces systemic inflammation, which stimulates the production of Ab and tau protein in the brain leading to Alzheimer's neuropathology (7). In addition to the low-grade chronic inflammation itself, periodontitis causes or promotes other chronic systemic inflammatory diseases, including atherosclerosis, cardiovascular disease, and diabetes, indicating that periodontitis is a significant source of systemic inflammatory molecules (6).…”

Section: Clinical Evidence For Periodontitis As a Potential Risk Factmentioning

confidence: 99%

Connection Between Periodontitis and Alzheimer’s Disease: Possible Roles of Microglia and Leptomeningeal Cells

Nakanishi

2014

J Pharmacol Sci

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Abstract. Neuroinflammation, inflammation of the brain, is strongly implicated in Alzheimer's disease (AD), which can be enhanced by systemic inflammation. Therefore, the initiation and progression of AD are affected by systemic diseases such as cardiovascular disease and diabetes. This concept suggests a possible link between periodontitis and AD because periodontitis is a peripheral, chronic infection that elicits a significant systemic inflammatory response. There is now growing clinical evidence that chronic periodontitis is closely linked to the initiation and progression of AD. Recent studies have suggested that leptomeningeal cells play an important role in transducing systemic inflammatory signals to the brain-resident microglia, which in turn initiate neuroinflammation. Furthermore, it is apparent that senescent-type microglia respond in an exaggerated manner to systemic inflammation. It is estimated that a high percentage of adults are suffering from periodontitis, and the prevalence of periodontitis increases with age. Therefore, chronic periodontitis can be a significant source of covert systemic inflammation within the general population. The present review article highlights our current understanding of the link between periodontitis and AD.

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Section: Clinical Evidence For Periodontitis As a Potential Risk Factmentioning

confidence: 99%

Connection Between Periodontitis and Alzheimer’s Disease: Possible Roles of Microglia and Leptomeningeal Cells

Nakanishi

2014

J Pharmacol Sci

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“…Inflammation, possibly within the central nervous system, is thought to have a pivotal role in the pathogenesis of dementia. 8 Studies examining the relation of oral disease with dementia are scarce, [11][12][13][14][15][16] and several have methodological shortcomings which hamper data interpretation. Case-control studies 11,12,17 are subject to the problem of reverse causality.…”

Section: Introductionmentioning

confidence: 99%

Oral Disease in Relation to Future Risk of Dementia and Cognitive Decline: Prospective Cohort Study Based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (Advance) Trial

et al. 2011

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Objective-Examine the association of oral disease with dementia/cognitive decline in a cohort of people with type 2 diabetes.Methods-A total of 11,140 men and women aged 55-88 years with type 2 diabetes participated in a baseline medical examination when they reported the number of natural teeth and days of bleeding gums. Dementia and cognitive decline were ascertained periodically during a 5 year follow-up.Results-Relative to the group with the greatest number of teeth (>=22), having no teeth was associated with the highest risk of both dementia (hazard ratio; 95% confidence interval: 1.48; 1.24, 1.78) and cognitive decline (1.39; 1.21, 1.59). Number of days of bleeding gums was unrelated to these outcomes. Conclusions-Tooth loss was associated with an increased risk of both dementia and cognitive decline. Europe PMC Funders Group

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“…8 patients had an important risk of infection because they had more than 10 roots and a periodontal inflammation [36][37][38].…”

Section: Inflammation and Infectious Riskmentioning

confidence: 99%

Oral Health in a Cognitive and Behavioral Unit

Pasca¹,

Rapp²,

Saidlitz³

et al. 2017

JDODT

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care project, ethical aspect. The professionals have skills and specific training. A structured and adapted program of activities is suggested in an objective limiting the expression of the behavior disorders and if possible to decrease the use of the sedative psychotropic and the setting. At the same time, the objectives in units of following and readaptation care are maintained. Nonmedical practices are proposed to these patients: psychomotricity, ergo therapy, orthophony, art-therapy… [8][9][10][11].The general clinical context is taken into account because symptoms associated as pains, discomfort, under nutrition, dehydration; infections can deteriorate behavioral disorders in dementia. Although they can affect the quality of life of elderly with dementia, the oral health is often neglected and the oral care is considered complicated. Indeed, the behavior disorders (agitation, aggression), the lack of cooperation even the opposition, the loss of autonomy, the disturbance of the physical marks are so many brakes in the access to healthcare dental [12][13][14][15][16][17][18][19][20][21][22][23][24][25].The Pole Geriatrics-Gerontology of the Toulouse University Hospital became aware of this fact and the oral health is a part of the global care of the hospitalized patients. ObjectiveThe main objective was to observe oral status of patients affected by Alzheimer's diseases and dementia (ADD) with intrusive behavior disorders. The secondary objective is to propose an adapted oral care. MethodsA cross-sectional study of the oral status was made by a clinical observation and a data collection on group of patients hospitalized in the CBU of Toulouse (Gérontopôle -Toulouse University Hospital). 138 patients were able to be examined.Considering the cognitive diseases, the consent was not able to be collected. The general, geriatric data were raised on computerized medical record. The oral status is systematically realized within the framework of a global health check-up.

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Inflammation and Alzheimer's disease: Possible role of periodontal diseases

Cited by 319 publications

References 47 publications

Connection Between Periodontitis and Alzheimer’s Disease: Possible Roles of Microglia and Leptomeningeal Cells

Connection Between Periodontitis and Alzheimer’s Disease: Possible Roles of Microglia and Leptomeningeal Cells

Oral Disease in Relation to Future Risk of Dementia and Cognitive Decline: Prospective Cohort Study Based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (Advance) Trial

Oral Health in a Cognitive and Behavioral Unit

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