J. Neurosci. Res. volume 86, issue 6, P1199-1208 2008 DOI: 10.1002/jnr.21585 View full text
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Sulagna Das, Anirban Basu

Abstract: Any pathological perturbation to the brain provokes a cascade of molecular and cellular events, which manifests in the form of microglial activation and release of various proinflammatory molecules. This eventually culminates in a profound neuroinflammatory reaction that characterizes the brain's response to stress, injury, or infection. The inflammatory cascade is an attempt by the system to eliminate the challenge imposed on the brain, clear the system of the dead and damaged neurons, and rescue the normal f…

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