Infertility May Sometimes Be Associated With Nsaid Consumption

Akıl, Muhammed; Amos, R S; Stewart, Peter

doi:10.1093/rheumatology/35.1.76

Cited by 80 publications

(42 citation statements)

References 2 publications

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“…The small percentage of follicles that do ovulate fail to be fertilized, most probably owing to impaired oocyte maturation (Lim et al, 1997). COX inhibitors, such as NSAIDs, cause reversible female infertility and may act in a similar manner (Akil et al, 1996;Pall et al, 2001;Smith et al, 1996). Like many mammals, Drosophila females also ovulate only one mature oocyte at a time, most probably by inducing contraction of the muscles surrounding just 845 RESEARCH ARTICLE Pxt encodes the Drosophila cyclooxygenase one of the more than 30 ovarioles that make up the two ovaries.…”

Section: Research Articlementioning

confidence: 99%

DrosophilaPxt: a cyclooxygenase-like facilitator of follicle maturation

2008

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Prostaglandins are local transient hormones that mediate a wide variety of biological events, including reproduction. The study of prostaglandin biology in a genetically tractable invertebrate model organism has been limited by the lack of clearly identified prostaglandin-mediated biological processes and prostaglandin metabolic genes, particularly analogs of cyclooxygenase (COX), the rate-limiting step in vertebrate prostaglandin synthesis. Here, we present pharmacological data that Drosophila ovarian follicle maturation requires COX-like activity and genetic evidence that this activity is supplied in vivo by the Drosophila peroxidase Pxt. pxt mutant females are sterile, and maturing follicles show defects in actin filament formation, nurse cell membrane stability and border cell migration. Maturation of pxt follicles in vitro is stimulated by prostaglandin treatment and fertility is restored in vivo to pxt mutants by expressing mammalian Cox1 protein. Our experiments suggest that prostaglandins promote Drosophila follicle maturation, in part by modulating the actin cytoskeleton, and establish Drosophila oogenesis as a model for understanding these critical biological regulators.

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Section: Research Articlementioning

confidence: 99%

DrosophilaPxt: a cyclooxygenase-like facilitator of follicle maturation

2008

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“…Dysfunctional ovulation was observed in half of the patients treated with lower dose and ninety percent in the patients treated with higher doses of meloxicam (21). Also in another study complete inhibition of ovulation has been achieved by 150-200 mg of indomethacin (22). This indicates that prostanoids must be reduced below a certain threshold to result in LUF syndrome.…”

Section: Percentage Reduction In Ovulation By Diclofenac Naproxen and mentioning

confidence: 93%

Effects of Some Non Steroidal Anti-inflammatory Drugs on Ovulation in Women with Mild Musculoskeletal Pain (A Clinical Study)

B.Q¹,

A.M²,

S.S³

2014

IOSRJPBS

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“…Dysfunctional ovulation was observed in 11 (50%) of 22 cycles treated with 15 mg/day and 20 (90.9%) of 22 cycles treated with 30 mg/day of meloxicam (16). Complete inhibition of ovulation has been achieved by 150 -200 mg of indomethacin (5,9). This indicates that prostanoids must be reduced below a certain threshold to result in LUF syndrome.…”

Section: Micu Et Almentioning

confidence: 99%

“…Previous studies comprising series of healthy women and case reports of women with rheumatic diseases (1,(5)(6)(7)(8)(9)(10)(11) demonstrated the occurrence of the LUF syndrome with exposure to inhibitors of cyclooxygenase 1 (COX-1) and COX-2. Placebo-controlled studies of healthy women exposed to NSAIDs showed delayed rupture of the follicle, but no modification of the hormonal cyclicity, although a decrease of progesterone was observed in some studies (5,7).…”

Section: Introductionmentioning

confidence: 99%

Luteinized unruptured follicle syndrome increased by inactive disease and selective cyclooxygenase 2 inhibitors in women with inflammatory arthropathies

Micu

Østensen

2011

Arthritis Care & Research

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Objective. Administration of nonsteroidal antiinflammatory drugs (NSAIDs) may impair fertility. The occurrence of the luteinized unruptured follicle (LUF) syndrome was assessed in women with inflammatory arthropathies exposed to NSAIDs and compared to that in nonexposed women. Methods. Fourteen patients with inflammatory rheumatic disease, 29 women with noninflammatory musculoskeletal conditions, and 449 women not exposed to NSAIDs were studied by intravaginal ultrasound monitoring for follicular development and ovulation in 1 or more menstrual cycles. Disease activity was assessed in inflammatory rheumatic disease. Results. In 59 monitored cycles of patients with continuous NSAID exposure, 35.6% of LUF syndromes occurred compared to 3.4% of LUF syndromes in untreated women (P < 0.001). Etoricoxib was responsible for 75% of LUF syndromes in patients exposed continuously, whereas diclofenac generated 15% of LUF syndromes. An ibuprofen dosage of 1,600 mg/day did not induce LUF syndrome either at continuous periovulatory or discontinuous exposure. Interestingly, the frequency of LUF syndrome was 46.2% in patients with inactive inflammatory disease compared to 15% in patients with active disease (P ‫؍‬ 0.023). Etoricoxib generated LUF syndrome in 94.2% of the cases with inactive disease versus 28.6% in patients with active disease (P ‫؍‬ 0.003). Conclusion. NSAIDs increased the risk of the LUF syndrome, particularly in patients with inactive disease. The selective cyclooxygenase 2 (COX-2) inhibitor etoricoxib was a more potent inductor of LUF syndrome than nonselective COX inhibitors. Continuous periovulatory exposure to NSAIDs should be avoided when planning a pregnancy in patients with rheumatic diseases.

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Infertility May Sometimes Be Associated With Nsaid Consumption

Cited by 80 publications

References 2 publications

DrosophilaPxt: a cyclooxygenase-like facilitator of follicle maturation

DrosophilaPxt: a cyclooxygenase-like facilitator of follicle maturation

Effects of Some Non Steroidal Anti-inflammatory Drugs on Ovulation in Women with Mild Musculoskeletal Pain (A Clinical Study)

Luteinized unruptured follicle syndrome increased by inactive disease and selective cyclooxygenase 2 inhibitors in women with inflammatory arthropathies

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