Infective endocarditis after transcatheter aortic valve implantation: Contributions of a single-centre experience on incidence and associated factors

Rodríguez-Vidigal, Francisco Félix; Nogales-Asensio, Juan Manuel; Calvo-Cano, Antonia; González-Fernández, Reyes; Martínez-Carapeto, Ana; Gómez-Sanchez, Inmaculada; Bengla-Limpo, Bruno; Antonio, Martín; Nogales-Muñoz, Nieves; Vera-Tomé, Araceli; Muñoz-Sanz, Agustín; López-Mínguez, José Ramón

doi:10.1016/j.eimce.2019.04.002

Cited by 8 publications

(17 citation statements)

References 17 publications

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“…Amat-Santos et al found that orotracheal intubation during general anaesthesia for the TAVI and the self-expandable CoreValve THV system were associated with IE in multivariate analysis [21]. Additionally, Rodríguez-Vidigal found that a history of cancer and that an increase in the EuroSCORE II were factors associated with an increased risk of TAVI-IE [33]. The pooled cohort of the PARTNER trials and registries, investigated by Summers et al, found that pulmonary disease, liver cirrhosis, prior or current cancer and post dilation were factors associated with an increased risk of TAVI-IE [32].…”

Section: Risk Factors Of Endocarditis In Tavimentioning

confidence: 99%

“…For the majority of the observational studies included in this review, identification of patients with TAVI-IE was mostly conducted with the modified Duke criteria. Two studies included patients with only definite IE [20,33], two studies identified patients with TAVI-IE through administrative registries using diagnosis codes from the International Classification of Diseases [14,28] and the rest of the studies included both patients with definite and possible IE [13,21e27]. In Table S2, distribution of definite and possible IE is shown for the observational studies included.…”

Section: Diagnosismentioning

confidence: 99%

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Infective endocarditis in patients who have undergone transcatheter aortic valve implantation: a review

Østergaard

Lauridsen

Iversen

et al. 2020

Clinical Microbiology and Infection

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Background: Transcatheter aortic valve implantation (TAVI) has been approved for the treatment of severe aortic stenosis since 2008 and recent trials have shown that TAVI is at least non-inferior to surgical aortic valve replacement (SAVR) with regards to short-term efficacy and safety in patients across all surgical risk profiles. Prosthetic valve endocarditis of the transcatheter heart valve is a feared complication; data on the risk of infective endocarditis (IE) subsequent to TAVI are now gradually emerging. Objectives: We set forth to conduct a review of the incidence, diagnosis, microbial aetiologies, prevention, outcome and management of TAVI-IE. Sources: From the MEDLINE database we included a total of 12 observational studies and five studies of long-term results from randomized controlled trials. Content: The incidence of TAVI-IE was reported to be between 0.7% and 3.0% per person-year. The most common microbes were reported to be enterococci, Staphylococcus aureus, streptococci and coagulasenegative staphylococci. International guidelines on prevention strategies of IE recommend good sanitary conditions including cutaneous care, good oral hygiene and good care of dialysis catheters. Antibiotic prophylaxis is recommended by guidelines prior to dental procedures in patients with TAVI; however, evidence is sparse. The majority of the patients included in this review with TAVI-IE had an indication for surgical intervention due to IE (50.0% or more); however, only a small subset of the patients underwent surgery (16.4% or less). The in-hospital mortality was around 25%, i.e. of the same order of magnitude as in prosthetic valve IE in general, but varied substantially between studies (from 11% to 64%). Implications: The US Food and Drug Administration's approval of TAVI in patients at low surgical risk may change the characteristics of patients with TAVI, which may influence the incidence, management, and outcome of patients with TAVI-IE.

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Section: Risk Factors Of Endocarditis In Tavimentioning

confidence: 99%

Section: Diagnosismentioning

confidence: 99%

Infective endocarditis in patients who have undergone transcatheter aortic valve implantation: a review

Østergaard

Lauridsen

Iversen

et al. 2020

Clinical Microbiology and Infection

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“…Sensitivity analysis did not reveal any significant changes. To evaluate the predictors of TAVI-IE, we pooled six cohort studies incorporating 507 patients suffering from TAVI-IE and 57531 patients free from IE (Amat-Santos et al, 2015;Mangner et al, 2016;Olsen et al, 2015;Regueiro et al, 2016;Rodriguez-Vidigal et al, 2018;Yeo et al, 2018). Patients with TAVI-IE were younger (TAVI-IE: 73.5 ± 4.2 vs. TAVI NON-IE: 79.9 ± 3.24, P < 0.001).…”

Section: Resultsmentioning

confidence: 99%

“…Moreover, intubation, new pacemaker implantation, and CKD were risk factors for TAVI-IE (RR: 2.99, 95% CI 2.73 to 3.28; RR: 5.19, 95% CI 4.16 to 6.47; and RR: 1.17, 95% CI 1.05 to 1.29). Other variables showed no significant statistics and are presented in Table 2. A total of 51 articles which reported individual data of 157 patients were identified, 3 observational studies (Amat-Santos et al, 2015;Olsen et al, 2015;Rodriguez-Vidigal et al, 2018), 5 case series (Aung et al, 2013;Gallouche et al, 2018;Martinez-Selles et al, 2016;Puls et al, 2013;Scisło et al, 2019), 43 case reports (Ahmad et al, 2016;Campana et al, 2019;Carnero-Alcazar et al, 2010;Carrel and Eberle, 2019;Castiglioni et al, 2012;Cho et al, 2019;Chourdakis et al, 2017;Citro et al, 2013;Comoglio et al, 2009;Dapas et al, 2016;García-Pardo et al, 2012;Gonzalez et al, 2017;Gotzmann and Mugge, 2011;Gupta et al, 2019;Gürtler et al, 2019;Halapas et al, 2014;Head et al, 2011;Kesimci et al, 2014;Lane et al, 2015;Lee et al, 2014Lee et al, , 2019Loh et al, 2013;Loverix et al, 2013;Montero-Cruces et al, 2019;Mori et al, 2019;Morioka et al, 2019;Nguyen et al, 2019;Ochiai et al, 2016;Ohori et al, 2018;…”

Section: Resultsmentioning

confidence: 99%

Infective endocarditis after TAVI: a meta-analysis and systematic review of epidemiology, risk factors and clinical consequences

Tinică¹,

Tarus²,

Enache³

et al. 2020

Reviews in Cardiovascular Medicine

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Infective endocarditis (IE) represents one of the most challenging clinical entities, requiring a multidisciplinary approach. The increasing number of surgical and transcatheter heart valves replacements performed annually lead to a higher incidence of prosthetic valve endocarditis. Transcatheter aortic valve implantation (TAVI) brought a new alternative for the treatment of aortic stenosis and a new subgroup of IE with its features. We aimed to compare the incidence of IE in TAVI and surgical valve replacement (SAVR) to identify risk factors for TAVI-IE, evaluate the possible impact on mortality, and clarify the best treatment strategies. A digital scan in PubMed and SCOPUS databases was performed. 68 publications were selected to perform a meta-analysis and systematic review on epidemiology, risk factors, and mortality predictors in TAVI-IE. No significant difference in IE rate was noted between patients with TAVI and those with SAVR for in-hospital, early, mid-term and late IE. Male gender, intubation, new pacemaker implantation IE and CKD were correlated with TAVI-IE. Surgical treatment was performed in 22.3% of cases. Overall mortality for the pooled cohort was 38.3%. In a multivariate logistic regression model, surgical treatment and self-expandable device were linked to lower mortality in TAVI-IE. Even if the invasive procedure can trigger bacteremia, exposing the TAVI valve to future infection, no significant difference in IE rate was noted in our analysis between patients with TAVI and those with SAVR for in-hospital, early, mid-term and late IE. Surgical treatment of TAVI-IE can be a viable option in patients with a prohibitive risk score.

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“…The development of medicine makes more and more medical devices used to treat human disease, the incidence of bio lm infection in these patients with indwelling medical devices is also increasing [1], which can cause the dysfunction of the device that is implanted [2] and serious complications [3]. For example, the incidence of infective endocarditis after transcatheter aortic valve implantation was 5.5%, after the occurrence of infective endocarditis, the in-hospital mortality was 36.4%, and the one-year mortality rate was as high as 54.5% [4].…”

Section: Introductionmentioning

confidence: 99%

Dormancy Induces the Formation of Persisters in the Candida Albicans-staphylococcus Epidermidis Mixed Species Biofilm

Yang

Xiang

Wang³

et al. 2021

Preprint

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Background: Persisters make biofilm infections difficult to cure, the low content of persisters in biofilm and the difficulty of obtaining them are outstanding problems in research, finding a reliable method to obtain a sufficient amount of persisters is the key to research. Methods: In this study, C.albicans strain ATCC10231 and S.epidermidis ATCC35984 were used to culture mixed biofilms on the surface of a titanium metal coupon. Tetracycline, gentamicin, 5-fluorocytosine(5-Fc), caspofungin, rifampicin, fluconazole and carbonyl cyanide m-chlorophenylhydrazone (CCCP) were used to induce the dormancy of biofilms to produce persisters. Ciprofloxacin and amphotericin B were used to kill the non dormant bacteria, and then the persisters were screened. Results:The study showed that dormancy induced by tetracycline and 5-Fc could significantly increase the persister levels of S.epidermidis and C.albicans, respectively. After the induced persisters were re-cultured, there was no significant change in antibiotic sensitivity compared with before induction.Scanning electron microscope(SEM) observations showed that after dormancy induction, the surface morphology of C.albicans in the mixed biofilm showed convex changes, and the volume of S.epidermidis decreased. Confocal laser scanning microscope (CLSM)observation showed that the mixed biofilm with high content of persisters did not dissolve under the killing of antibiotics, and the biofilm with low content of persisters dissolved in large area. Conclusions: Induction of dormancy is a reliable method for the formation of persistent bacteria in C.albicans-S.epidermidis mixed biofilm.

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Infective endocarditis after transcatheter aortic valve implantation: Contributions of a single-centre experience on incidence and associated factors

Cited by 8 publications

References 17 publications

Infective endocarditis in patients who have undergone transcatheter aortic valve implantation: a review

Infective endocarditis in patients who have undergone transcatheter aortic valve implantation: a review

Infective endocarditis after TAVI: a meta-analysis and systematic review of epidemiology, risk factors and clinical consequences

Dormancy Induces the Formation of Persisters in the Candida Albicans-staphylococcus Epidermidis Mixed Species Biofilm

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