Infectious Ulcerative Keratitis Following Retinopathy of Prematurity Treatment

Modi, Kunjal K; Chu, David; Wagner, Rudolph S; Guo, Suqin; Zarbin, Marco A.; Bhagat, Neelakshi

doi:10.3928/01913913-20150602-01

Cited by 4 publications

(6 citation statements)

References 22 publications

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“…noted corneal epithelial defects in 10 of 110 eyes (9.1%) treated for ROP, with progression to ulcerative keratitis in 4 of 98 (4.08%) of eyes treated with laser. [ 6 ] The authors emphasized the potential of corneal epithelial defects after laser to develop into ulcerative keratitis. [ 6 ] Potential corneal scarring is particularly important in neonates given the potential for deprivation amblyopia.…”

Section: Discussionmentioning

confidence: 99%

“…[ 6 ] The authors emphasized the potential of corneal epithelial defects after laser to develop into ulcerative keratitis. [ 6 ] Potential corneal scarring is particularly important in neonates given the potential for deprivation amblyopia. Accordingly, it is appropriate to take reasonable steps to reduce the risk of corneal epithelial defects after laser for ROP.…”

Section: Discussionmentioning

confidence: 99%

“…[ 3 4 5 ] While generally safe and effective, adverse outcomes have been reported after laser treatments for ROP, including corneal epithelial defects and opacities. [ 6 7 ] While risks of treatment for ROP have been described, methods to decrease these risks have not been firmly established. [ 7 8 9 10 11 12 ] Our goal is to compare the incidence of corneal epithelial defects after laser for ROP with and without the use of postoperative erythromycin ointment.…”

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confidence: 99%

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Risk of corneal epithelial defects with and without postoperative erythromycin ointment after laser photocoagulation for retinopathy of prematurity

Khan

Chebolu

Richards

et al. 2021

Indian Journal of Ophthalmology

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Purpose: We aim to compare the incidence of corneal epithelial defects after laser for retinopathy of prematurity (ROP) with and without the use of postoperative erythromycin ointment. Methods: In this retrospective observational cohort study, a total of 100 infants (200 eyes) consecutively treated with laser for ROP between 2012 and 2018. The primary outcome was presence or absence of corneal epithelial defect using fluorescein on bedside examination within the first week following laser for ROP. Additional data assessed included: the use of postoperative prophylactic erythromycin ointment for 1 week, postoperative day on which examination using fluorescein occurred, presence of corneal opacity, gender, birth weight, and gestation age. The presence or absence of postoperative corneal epithelial defects was compared between eyes receiving postoperative erythromycin ointment or not using a Fisher's exact test. Results: Postoperative corneal epithelial defects were more common in eyes which did not receive postoperative erythromycin (7 of 40 eyes; 17.5%), compared to eyes which did receive erythromycin (1 of 160 eyes; 0.6%; P < 0.0001). Postoperative bedside examinations with fluorescein were performed within 2 days of surgery on 136 of 200 of eyes (68%). Corneal opacities were noted in 3 of 200 eyes (1.5%). Conclusion: We observed less corneal epithelial defects in eyes which received postoperative erythromycin ointment for 1 week after laser for ROP than in those which did not. While multiple variables may influence the presence or absence of postoperative corneal epithelial defects following laser for ROP, consideration for postoperative lubricating ointment following laser for ROP seems reasonable.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Risk of corneal epithelial defects with and without postoperative erythromycin ointment after laser photocoagulation for retinopathy of prematurity

Khan

Chebolu

Richards

et al. 2021

Indian Journal of Ophthalmology

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“…However, these methods focus on the late stages and do not address the underlying pathological defects. Each has significant safety implications [ 149 ], such as ulcerative keratitis, intravitreous vascular hyperplasia, retinal detachment, and sustained retinal vascularization [ 150 , 151 , 152 , 153 ]. Therefore, it is important to search for safer and more effective treatments.…”

Section: Application Of Scs In Refractory Diseases Of Newbornsmentioning

confidence: 99%

Progress in Research on Stem Cells in Neonatal Refractory Diseases

Huang,

He,

Zhang

et al. 2023

JPM

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With the development and progress of medical technology, the survival rate of premature and low-birth-weight infants has increased, as has the incidence of a variety of neonatal diseases, such as hypoxic–ischemic encephalopathy, intraventricular hemorrhage, bronchopulmonary dysplasia, necrotizing enterocolitis, and retinopathy of prematurity. These diseases cause severe health conditions with poor prognoses, and existing control methods are ineffective for such diseases. Stem cells are a special type of cells with self-renewal and differentiation potential, and their mechanisms mainly include anti-inflammatory and anti-apoptotic properties, reducing oxidative stress, and boosting regeneration. Their paracrine effects can affect the microenvironment in which they survive, thereby affecting the biological characteristics of other cells. Due to their unique abilities, stem cells have been used in treating various diseases. Therefore, stem cell therapy may open up the possibility of treating such neonatal diseases. This review summarizes the research progress on stem cells and exosomes derived from stem cells in neonatal refractory diseases to provide new insights for most researchers and clinicians regarding future treatments. In addition, the current challenges and perspectives in stem cell therapy are discussed.

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“…Laser photocoagulation was found to cause infectious ulcerative keratitis in a subgroup of ROP infants. The mechanism involved postoperative corneal epithelial defects that led to corneal haze 14. Another study of long-term ophthalmological outcomes in children treated for threshold ROP by indirect laser photocoagulation reported that these patients had higher risks of strabismus, astigmatism, nystagmus, myopia, and lowered visual acuity compared to the control subjects, infants with spontaneously regressed ROP 15…”

Section: Mechanisms and Current Therapies For Ropmentioning

confidence: 99%

Promoting vascular repair in the retina: can stem/progenitor cells help?

Trinh¹,

Calzi²,

Shaw³

et al. 2016

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Since its first epidemic in the 1940s, retinopathy of prematurity (ROP) has been a challenging illness in neonatology. Higher than physiological oxygen levels impede the development of the immature retinal neuropil and vasculature. Current treatment regimens include cryotherapy, laser photocoagulation, and anti-VEGF agents. Unfortunately, none of these approaches can rescue the normal retinal vasculature, and each has significant safety concerns. The limitations of these approaches have led to new efforts to understand the pathological characteristics in each phase of ROP and to find a safer and more effective therapeutic approach. In the era of stem cell biology and with the need for new treatments for ROP, this review discusses the possible future use of unique populations of proangiogenic cells for therapeutic revascularization of the preterm retina.

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Infectious Ulcerative Keratitis Following Retinopathy of Prematurity Treatment

Abstract: Infectious ulcerative keratitis developed in a small, but significant, percentage of patients undergoing treatment for ROP. Postoperative corneal epithelial defects with subsequent corneal haze appear to be involved in the progression to ulcerative keratitis.

Cited by 4 publications

References 22 publications

Risk of corneal epithelial defects with and without postoperative erythromycin ointment after laser photocoagulation for retinopathy of prematurity

Risk of corneal epithelial defects with and without postoperative erythromycin ointment after laser photocoagulation for retinopathy of prematurity

Progress in Research on Stem Cells in Neonatal Refractory Diseases

Promoting vascular repair in the retina: can stem/progenitor cells help?

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