Infections in Renal Transplant Patients: Risk Factors and Infectious Agents

Ak, Öznur; Yıldırım, Mehmet; Küçük, Hasan Fehmi; Gençer, Serap; Demir, Tuba Öztürk

doi:10.1016/j.transproceed.2013.02.080

Cited by 41 publications

(47 citation statements)

References 15 publications

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Section: Discussionmentioning

confidence: 99%

“…3,7,[11][12][13] Immunosuppressive agents and contamination by outside environmental sources are the 2 major risk factors that reportedly affect UTI rate, especially within the first 6 months after RT. 2,7,14 Studies have reported UTI rates of 35% to 79% after transplant. 2,7,12,[14][15][16][17] Urinary tract infections are the cause of infectious complications and hospital admissions and 70% of deaths associated with sepsis (48%) and pneumonia (22%).…”

Section: Discussionmentioning

confidence: 99%

“…2,7,14 Studies have reported UTI rates of 35% to 79% after transplant. 2,7,12,[14][15][16][17] Urinary tract infections are the cause of infectious complications and hospital admissions and 70% of deaths associated with sepsis (48%) and pneumonia (22%). 18 During the past 25 years, however, infection-related deaths have been decreasing.…”

Section: Discussionmentioning

confidence: 99%

“…A study by Ak and associates 7 from Turkey reported that 40.3% of 124 patients developed infections, of which 85% were UTIs, 10% were bacteremia, 4.5% were intra-abdominal infections, 3.4% were surgical field infections, and 3.4% were central venous catheter infections. The most common causative microbial agents were Escherichia coli (56.6%) and Klebsiella pneumoniae (13.2%).…”

Section: Discussionmentioning

confidence: 99%

“…[4][5][6] In addition to UTIs, sepsis, pneumonia, and surgical field infections are also common. [7][8][9][10] Posttransplant infections create significant morbidity and mortality for affected patients. They also cause prolonged hospital stays, create susceptibility for new infections, and increase treatment costs.…”

Section: Introductionmentioning

confidence: 99%

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Yabanoğlu

Alışkan²,

Çalışkan³

et al. 2015

Exp Clin Transplant

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Objectives: This study aimed to compare renal transplant recipients with and without infection with respect to demographic and clinical characteristics as well as risk factors; to determine the incidence of posttransplant infections; and to study the antibiotic resistance patterns of bacterial species identified as the causative organisms in posttransplant infections. Materials and Methods: This study included a total of 136 patients undergoing renal transplant in a 4-year period. The patients were categorized into 2 groups. The 2 groups were compared with each other with respect to general clinical and demographic variables and the number and frequency of infectious attacks within a 1-year follow-up, infection type, and antibiotic resistance patterns. Results: Ninety-two (67.6%) of the subjects were male and 44 (32.4%) were female. A total of 57 (41.9%) patients developed 128 infectious attacks. Urinary tract infections were the most common infections (42.1%). There was a significant correlation between a clinically relevant urinary culture proliferation and postoperative infection rate (P = .002). There was a significant correlation between antimicrobial resistance and the number of infectious attacks (P = .023). There was a significant correlation between the proliferation of Extended Spectrum Beta Lactamase-positive Enterobactericeae species and the number of infectious attacks (P = .000). Conclusions: Presence of a clinically relevant proliferation in the preoperative urinary culture, which was identified as a risk factor for infection, increased the number of infectious attacks. Moreover, Extended Spectrum Beta Lactamasepositive Enterobactericeae species increased the number of infections. These 2 principle results should be taken into account in patient management.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Untitled

Yabanoğlu

Alışkan²,

Çalışkan³

et al. 2015

Exp Clin Transplant

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Oral shedding of human herpesviruses in renal transplant recipients

et al. 2017

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Single-center analysis of infectious complications in older adults during the first year after kidney transplantation

Hemmersbach‐Miller

Alexander

Sudan

et al. 2018

Eur J Clin Microbiol Infect Dis

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Purpose: Infections are among the top three causes of death of older adults in the first year after kidney transplantation (KT). Our aim was to describe infectious complications among KT recipients aged ≥65 during the first 12 months post-transplant. Methods: Single center retrospective cohort study. Results: Ninety-one KTs had been performed in patients ≥ 65 years of age between 2011–2015. 92.3% of the patients developed at least one infection. Infectious episodes increased the risk of future infection by 10% (p=0.0018) with each infection portending a greater risk. At a patient level, viral (71.4%) and bacterial (70.2%) infections predominated. Urinary tract infections were the most frequent complication (30.3%), followed by cytomegalovirus infections (22.7%). Infections were the main reason for readmission. 7.7% of the patients developed rejection; and overall 3.3% lost their graft. Mortality at one year was 9.9%. Conclusions: Older KT recipients have a high incidence of infectious complications the first year after KT. Infections were the number one reason for readmission, and an infection episode predicted future infections for the individual patient. Despite these complications, the majority of older KT recipients were alive with a functioning graft at one-year.

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Infections in Renal Transplant Patients: Risk Factors and Infectious Agents

Cited by 41 publications

References 15 publications

Untitled

Untitled

Oral shedding of human herpesviruses in renal transplant recipients

Single-center analysis of infectious complications in older adults during the first year after kidney transplantation

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