2020
DOI: 10.3389/fmicb.2020.01422
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Abstract: In developed countries, hematological malignancies (HM) account for 8 to 10% of cancers diagnosed annually and one-third of patients with HM (HMP) are expected to die from their disease. The former wide spectrum "magic bullet," imipenem, has been ousted by the emergence of carbapenem resistant (CR) pathogens. In endemic areas, infections with CR-bacteria occur in vulnerable patients, notably in HMP, who suffer from high mortality related to infectious complications. In this work, we reviewed epidemiologic and … Show more

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Cited by 28 publications
(27 citation statements)
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References 93 publications
(215 reference statements)
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“…In 2020, Lalaoui et al [ 56 ] reviewed series and selected case reports studying epidemiological and clinical infections due to carbapenem-resistant GNB in patients with HM [ 2 , 3 , 6 , 17 , 18 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 ]. In their study, resistance profiles of strains involved mainly reflected local epidemiology, and they observed that significant risk factors associated with infections with CRE included male, age around 50 years old, AL, selvage chemotherapy, neutropenia, and digestive tract colonization by carbapenem-resistant bacteria.…”
Section: The Epidemiology Of Cre In Hm Patientsmentioning
confidence: 99%
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“…In 2020, Lalaoui et al [ 56 ] reviewed series and selected case reports studying epidemiological and clinical infections due to carbapenem-resistant GNB in patients with HM [ 2 , 3 , 6 , 17 , 18 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 ]. In their study, resistance profiles of strains involved mainly reflected local epidemiology, and they observed that significant risk factors associated with infections with CRE included male, age around 50 years old, AL, selvage chemotherapy, neutropenia, and digestive tract colonization by carbapenem-resistant bacteria.…”
Section: The Epidemiology Of Cre In Hm Patientsmentioning
confidence: 99%
“…Globally, CRE strains demonstrate susceptibility to colistin in 80–100%, tigecycline in 60–80%, and gentamicin in 10–60% of HM patients [ 56 ]. The highest level of aminoglycoside resistance was observed in India [ 58 ] and Italy [ 62 ], where CRKp isolates with a high minimum inhibitory concentration (MIC) to gentamicin, tigecycline, and colistin were reported [ 106 ].…”
Section: Management Of Cre Infections In Adult Acute Leukemia Patimentioning
confidence: 99%
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“…Carbapenem-resistant gram-negative bacteria (CR-GNB) infections are an urgent global public health threat with high mortality rate ( 1 ). According to the standard of Clinical and Laboratory Standards Institute (CLSI), minimum inhibitory concentrations (MICs) of both imipenem and meropenem ≥8 mg/L means carbapenem-resistance, and MIC ≥4 mg/L means intermediate susceptibility ( 2 ).…”
Section: Introductionmentioning
confidence: 99%