Infection of the Human Eye With Cryptococcus Neoformans (Torula Histolytica; Cryptococcus Hominis)

A case of fatal cryptococcus meningitis with intraventricular granuloma

“…Finally, one cannot exclude the conjunctivae as the place of entry, this being supported by a history of recurrent conjunctivitis since 1967. This has also been described in a case reported by Weiss et al in 1948. Although massive fungicidal therapy was instituted immediately after diagnosis, death one month later could not be averted. After establishment in the internal CSF spaces, the organisms had caused multiple granulomas of the plexus in the lateral ventricles, as in the case described by Manganiello and Nichols in 1955, and also an apparently more recent large mycetoma in the right ventricle.…”

A case of fatal cryptococcus meningitis with intraventricular granuloma

“…Finally, one cannot exclude the conjunctivae as the place of entry, this being supported by a history of recurrent conjunctivitis since 1967. This has also been described in a case reported by Weiss et al in 1948. Although massive fungicidal therapy was instituted immediately after diagnosis, death one month later could not be averted. After establishment in the internal CSF spaces, the organisms had caused multiple granulomas of the plexus in the lateral ventricles, as in the case described by Manganiello and Nichols in 1955, and also an apparently more recent large mycetoma in the right ventricle.…”

Involvement of C3a and C5a in Interleukin-8 Secretion by Human Polymorphonuclear Cells in Response to Capsular Material ofCryptococcus neoformans

“…Cooperation between PMN and humoral defense mechanisms is demonstrated by the fact that killing of C. neoformans by neutrophils is most efficient when complementderived opsonins (3,6) or capsule-binding antibodies (28) are present. PMN are part of the inflammatory response to C. neoformans infection and are sometimes found in close asso-ciation with yeast cells (12,25,39). Evidence for the importance of PMN in protection against C. neoformans comes from mouse studies showing that PMN depletion enhances susceptibility to infection (15) whereas administration of recombinant granulocyte colony-stimulating factor enhances resistance to infection (14).…”

Cryptococcal eye disease

“…(a) Anterior Uveitis (Friedenwald et al, 1952;DeBuen et al, 1954;Wager & Calhoun, 1954;Sciortino et al, 1958;Weiss et al, 1948;Hiles & Font, 1968;Grieco & Freilich, 1971;Ehrhorn et al, 1976) can be severe enough to have an hypopian or secondary glaucoma. (b) Posterior Uveitis can take several forms.…”

A case of fatal cryptococcus meningitis with intraventricular granuloma

“…Finally, one cannot exclude the conjunctivae as the place of entry, this being supported by a history of recurrent conjunctivitis since 1967. This has also been described in a case reported by Weiss et al in 1948. Although massive fungicidal therapy was instituted immediately after diagnosis, death one month later could not be averted. After establishment in the internal CSF spaces, the organisms had caused multiple granulomas of the plexus in the lateral ventricles, as in the case described by Manganiello and Nichols in 1955, and also an apparently more recent large mycetoma in the right ventricle.…”

Involvement of C3a and C5a in Interleukin-8 Secretion by Human Polymorphonuclear Cells in Response to Capsular Material ofCryptococcus neoformans

“…Cooperation between PMN and humoral defense mechanisms is demonstrated by the fact that killing of C. neoformans by neutrophils is most efficient when complementderived opsonins (3,6) or capsule-binding antibodies (28) are present. PMN are part of the inflammatory response to C. neoformans infection and are sometimes found in close asso-ciation with yeast cells (12,25,39). Evidence for the importance of PMN in protection against C. neoformans comes from mouse studies showing that PMN depletion enhances susceptibility to infection (15) whereas administration of recombinant granulocyte colony-stimulating factor enhances resistance to infection (14).…”

Cryptococcal eye disease

“…(a) Anterior Uveitis (Friedenwald et al, 1952;DeBuen et al, 1954;Wager & Calhoun, 1954;Sciortino et al, 1958;Weiss et al, 1948;Hiles & Font, 1968;Grieco & Freilich, 1971;Ehrhorn et al, 1976) can be severe enough to have an hypopian or secondary glaucoma. (b) Posterior Uveitis can take several forms.…”

A case of fatal cryptococcus meningitis with intraventricular granuloma

“…Finally, one cannot exclude the conjunctivae as the place of entry, this being supported by a history of recurrent conjunctivitis since 1967. This has also been described in a case reported by Weiss et al in 1948. Although massive fungicidal therapy was instituted immediately after diagnosis, death one month later could not be averted. After establishment in the internal CSF spaces, the organisms had caused multiple granulomas of the plexus in the lateral ventricles, as in the case described by Manganiello and Nichols in 1955, and also an apparently more recent large mycetoma in the right ventricle.…”

Involvement of C3a and C5a in Interleukin-8 Secretion by Human Polymorphonuclear Cells in Response to Capsular Material ofCryptococcus neoformans

“…Cooperation between PMN and humoral defense mechanisms is demonstrated by the fact that killing of C. neoformans by neutrophils is most efficient when complementderived opsonins (3,6) or capsule-binding antibodies (28) are present. PMN are part of the inflammatory response to C. neoformans infection and are sometimes found in close asso-ciation with yeast cells (12,25,39). Evidence for the importance of PMN in protection against C. neoformans comes from mouse studies showing that PMN depletion enhances susceptibility to infection (15) whereas administration of recombinant granulocyte colony-stimulating factor enhances resistance to infection (14).…”

Cryptococcal eye disease

“…(a) Anterior Uveitis (Friedenwald et al, 1952;DeBuen et al, 1954;Wager & Calhoun, 1954;Sciortino et al, 1958;Weiss et al, 1948;Hiles & Font, 1968;Grieco & Freilich, 1971;Ehrhorn et al, 1976) can be severe enough to have an hypopian or secondary glaucoma. (b) Posterior Uveitis can take several forms.…”