Infection Due to 3 Avian Influenza Subtypes in United States Veterinarians

Myers, Kendall P.; Setterquist, Sharon F.; Capuano, Ana W.; Gray, Gregory C.

doi:10.1086/518579

Cited by 122 publications

(114 citation statements)

References 14 publications

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“…29 Avian influenza A(H6N1) viruses commonly circulate in domestic bird populations in the region 30 and throughout the world. Although previous serological studies have documented antibodies to influenza A(H6) in humans 31,32,33 this is the first report of a symptomatic human infection with an avian influenza A(H6N1) virus. Taipei CDC reported that the genome sequence of the virus isolated from the case was highly similar to avian influenza A(H6N1) viruses circulating in local domestic poultry.…”

Section: Human Infection With Influenza A(h6n1) Virusesmentioning

confidence: 79%

“…There were 39 human cases reported, an increase from the 32 A(H5N1) 3 compared to 18% of environmental samples collected from LBMs in Cambodia in 2011. 4 Several countries in Asia, including the Lao People's Democratic Republic (Lao PDR), Myanmar and Nepal, also regularly experience sporadic outbreaks of infection in poultry.…”

Section: Human Infection With Influenza A(h5n1) Virusesmentioning

confidence: 99%

“…29 Des virus de la grippe aviaire A(H6N1) circulent couramment dans les populations d'oiseaux domestiques de la région 30 et dans le monde entier. Bien que des études sérologiques anté-rieures aient attesté la présence d'anticorps contre la grippe A(H6) chez l'homme, 31,32,33 c'est le premier rapport d'une infection humaine symptomatique avec un virus de la grippe aviaire A(H6N1). Les CDC de Taipei ont indiqué que la séquence géno-mique du virus isolé à partir du cas était très similaire à celle des virus de la grippe aviaire A(H6N1) en circulation chez les volailles domestiques locales.…”

Section: Human Infections With Influenza A(h10n8) Virusesunclassified

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Sensitivity and Specificity Estimation for the Clinical Diagnosis of Highly Pathogenic Avian Influenza in the Egyptian Participatory Disease Surveillance Program

Verdugo

Masry²,

Makonnen³

et al. 2016

Avian Diseases

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Section: Human Infection With Influenza A(h6n1) Virusesmentioning

confidence: 79%

Section: Human Infection With Influenza A(h5n1) Virusesmentioning

confidence: 99%

Section: Human Infections With Influenza A(h10n8) Virusesunclassified

See 1 more Smart Citation

Sensitivity and Specificity Estimation for the Clinical Diagnosis of Highly Pathogenic Avian Influenza in the Egyptian Participatory Disease Surveillance Program

Verdugo

Masry²,

Makonnen³

et al. 2016

Avian Diseases

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“…26,27 However, several studies indicate that workers have been infected during AI outbreaks in poultry. [27][28][29][30][31][32][33] A serological evaluation of workers exposed during the HPAI H5N1 outbreak in Hong Kong in 1997 found that approximately 3% of government workers involved in the poultry culling operation and 10% of poultry workers were seropositive. 28 During a 2003 outbreak of HPAI H7N7 in the Netherlands, infection was confirmed in 89 people, with conjunctivitis being the predominant symptom reported.…”

Section: Discussionmentioning

confidence: 99%

Protecting Poultry Workers from Exposure to Avian Influenza Viruses

et al. 2008

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Emerging zoonotic diseases are of increasing regional and global importance. Preventing occupational exposure to zoonotic diseases protects workers as well as their families, communities, and the public health. Workers can be protected from zoonotic diseases most effectively by preventing and controlling diseases in animals, reducing workplace exposures, and educating workers. Certain avian influenza viruses are potential zoonotic disease agents that may be transmitted from infected birds to humans. Poultry workers are at risk of becoming infected with these viruses if they are exposed to infected birds or virus-contaminated materials or environments. Critical components of worker protection include educating employers and training poultry workers about occupational exposure to avian influenza viruses. Other recommendations for protecting poultry workers include the use of good hygiene and work practices, personal protective clothing and equipment, vaccination for seasonal influenza viruses, antiviral medication, and medical surveillance. Current recommendations for protecting poultry workers from exposure to avian influenza viruses are summarized in this article.

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“…antibodies have been detected in live animal market workers in China and in veterinarians exposed to birds in the United States (Shortridge 1992;Myers et al, 2007). Furthermore, two of 11 healthy human volunteers inoculated with the H6N1 virus displayed mild upper respiratory symptoms, suggesting that this virus has the potential to infect mammals (Beare and Webster, 1991).…”

Section: Co-circulating H5n2 Infl Uenza Viruses Reassorted With H6n1 mentioning

confidence: 99%

Origin and molecular characterization of the human-infecting H6N1 influenza virus in Taiwan

Shi

et al. 2013

Protein Cell

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In June 2013, the fi rst human H6N1 infl uenza virus infection was confirmed in Taiwan. However, the origin and molecular characterization of this virus, A/Taiwan/2/2013 (H6N1), have not been well studied thus far. In the present report, we performed phylogenetic and coalescent analyses of this virus and compared its molecular profi le/characteristics with other closely related strains. Molecular characterization of H6N1 revealed that it is a typical avian infl uenza virus of low pathogenicity, which might not replicate and propagate well in the upper airway in mammals. Phylogenetic analysis revealed that the virus clusters with A/chicken/Taiwan/A2837/2013 (H6N1) in seven genes, except PB1. For the PB1 gene, A/Taiwan/2/2013 was clustered with a different H6N1 lineage from A/chicken/Taiwan/ A2837/2013. Although a previous study demonstrated that the PB2, PA, and M genes of A/Taiwan/2/2013 might be derived from the H5N2 viruses, coalescent analyses revealed that these H5N2 viruses were derived from more recent strains than that of the ancestor of A/Taiwan/2/2013. Therefore, we propose that A/Taiwan/2/2013 is a reassortant from different H6N1 lineages circulating in chickens in Taiwan. Furthermore, compared to avian isolates, a single P186L (H3 numbering) substitution in the hemagglutinin H6 of the human isolate might increase the mammalian receptor binding and, hence, this strain's pathogenicity in humans. Overall, human infection with this virus seems an accidental event and is unlikely to cause an infl uenza pandemic. However, its co-circulation and potential reassortment with other infl uenza subtypes are still worthy of attention.

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Infection Due to 3 Avian Influenza Subtypes in United States Veterinarians

Cited by 122 publications

References 14 publications

Sensitivity and Specificity Estimation for the Clinical Diagnosis of Highly Pathogenic Avian Influenza in the Egyptian Participatory Disease Surveillance Program

Sensitivity and Specificity Estimation for the Clinical Diagnosis of Highly Pathogenic Avian Influenza in the Egyptian Participatory Disease Surveillance Program

Protecting Poultry Workers from Exposure to Avian Influenza Viruses

Origin and molecular characterization of the human-infecting H6N1 influenza virus in Taiwan

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