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Cited by 10 publications
(5 citation statements)
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References 5 publications
(5 reference statements)
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“…It is hypothesized that post infection, HTLV-I advances the in vivo clonal proliferation of HTLV-I infected cells through the functions of encoded viral proteins, including Tax [ 155 ]. If exposed to pathogens, mice with monoallelic loss of the B-cell transcription factor PAX5 are predisposed to B-cell ALL [ 147 , 156 ].…”
Section: Infectionsmentioning
confidence: 99%
“…It is hypothesized that post infection, HTLV-I advances the in vivo clonal proliferation of HTLV-I infected cells through the functions of encoded viral proteins, including Tax [ 155 ]. If exposed to pathogens, mice with monoallelic loss of the B-cell transcription factor PAX5 are predisposed to B-cell ALL [ 147 , 156 ].…”
Section: Infectionsmentioning
confidence: 99%
“…An epidemiological study based in Sweden revealed that history of any infectious disease was associated with a 1.3-fold significantly increased risk of acute myeloid leukaemia (AML) or myelodysplastic syndrome, even when infection had occurred years before onset [ 54 ]. In addition, infection seems to be a causal factor in childhood acute lymphoblastic leukaemia [ 55 , 56 ]. Chronic inflammation and autoimmune diseases have also been linked with increased risk of malignant lymphomas in adults [ 57 ].…”
Section: Inflammageing and Its Relation To Hsc Ageingmentioning
confidence: 99%
“…18 Notably, concomitant with rising levels of hygiene standards, the incidence of pB-ALL has increased in developed societies. [19][20][21][22] Epidemiologic studies have identified day care attendance, 23 birth order, 24 mode of delivery, 25,26 and breast feeding 27 as factors that influence the risk that a child might develop leukemia. Thus, delayed or disturbed immunologic training might lead to dysregulated immune responses when challenged with infectious agents.…”
Section: Introductionmentioning
confidence: 99%