Infantile Pyramidal Protrusion as a Manifestation of Lichen Sclerosus et Atrophicus

Cruces, Manuel; Torre, Carlos de la; Losada, Antonio; Ocampo, Concepción; García‐Doval, I.

doi:10.1001/archderm.134.9.1118

Cited by 52 publications

(53 citation statements)

References 7 publications

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“…In our experience, no nodule was pyramidal in shape; the lesions were peanut-, hen’s crest-, or tongue tip-like. We therefore agree with Cruces et al [3]. …”

Section: Discussionsupporting

confidence: 94%

“…Cruces et al [3]reported 4 female patients with this nodule and advocated that infantile perineal protrusion (IPNP) would be a more appropriate name, because the nodule shape was not always pyramidal. In addition, histopathologic examination of the nodules in these 4 girls revealed findings characteristic of lichen sclerosus et atrophicus.…”

Section: Discussionmentioning

confidence: 99%

“…Cruces et al [3]claim that IPNP is a manifestation of vulvar lichen sclerosus et atrophicus. However, none of our 36 patients with nodules showed any clinical or histologic change characteristic of this abnormality.…”

Section: Discussionmentioning

confidence: 99%

“…However, Cruces et al [3]indicated the shape was not always pyramidal and advocated that ‘infantile perineal protrusion’ would be an appropriate name. In our experience, no nodule was pyramidal in shape; the lesions were peanut-, hen’s crest-, or tongue tip-like.…”

Section: Discussionmentioning

confidence: 99%

“…This nodule is called perianal skin tags/folds [1], infantile perianal pyramidal protrusion [2], or infantile perineal protrusion [3]. …”

Section: Introductionmentioning

confidence: 99%

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Infantile Perineal Protrusion: A Statistical, Clinical, and Histopathologic Study

et al. 2000

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Background: Review of the literature of the peculiar nodule in the perineum of female infants disclosed that the analysis of incidence by gender, observation of the course, histopathologic assessment, and the pathogenesis of the abnormality was suboptimal. Objective: We therefore planned to study a large number of children to analyze the incidence by gender, the course, and the pathogenesis of the peculiar perineal nodules. Methods: Of 500 children (224 boys and 276 girls) who ranged from newborn to 11 years of age, occurrence of the perineal nodules was checked. When nodules were found, the site, shape, size, number, and the onset were examined. Histopathologic examination and observation of the course were carried out in some cases. Results: None of the boys in our population had nodules, but 13% of the girls did. These lesions always occurred as a single peanut-, hen’s crest-, or tongue tip-shaped nodule on the perineal midline, and 93% of the lesions had been present since birth. Histologically, the nodule was an outward projection of essentially normal, redundant skin, showing no evidence of lichen sclerosus et atrophicus. Conclusion: In view of these findings, we conclude that perineal nodules are a kind of developmental anomaly occurring mostly in girls.

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“…In our experience, no nodule was pyramidal in shape; the lesions were peanut-, hen’s crest-, or tongue tip-like. We therefore agree with Cruces et al [3]. …”

Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…This nodule is called perianal skin tags/folds [1], infantile perianal pyramidal protrusion [2], or infantile perineal protrusion [3]. …”

Section: Introductionmentioning

confidence: 99%

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Infantile Perineal Protrusion: A Statistical, Clinical, and Histopathologic Study

et al. 2000

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Successful Treatment of Anogenital Lichen Sclerosus With Topical Tacrolimus

Böhm¹,

Frieling²,

Luger³

et al. 2003

Arch Dermatol

111

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Background: Lichen sclerosus of the anogenital area is a chronic inflammatory and fibrosclerotic disease associated with substantial morbidity. Topical ultrapotent corticosteroids are currently the treatment of choice. Observations: Three prepubertal girls and 3 adults (2 men, 1 woman) were treated with 0.1% tacrolimus ointment once daily. All patients experienced complete resolution with long-lasting remission for up to 1 year. No major adverse effects were observed, and treatment was well tolerated. Conclusions: Topical tacrolimus is a promising novel agent in the treatment of lichen sclerosus of the anogenital area. A major advantage over topical corticosteroids is the lack of skin atrophy. Further clinical trials are warranted to confirm our findings.

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Genital Disease in Children

Fischer¹

2019

Harper's Textbook of Pediatric Dermatology

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Infantile Pyramidal Protrusion as a Manifestation of Lichen Sclerosus et Atrophicus

Cited by 52 publications

References 7 publications

Infantile Perineal Protrusion: A Statistical, Clinical, and Histopathologic Study

Infantile Perineal Protrusion: A Statistical, Clinical, and Histopathologic Study

Successful Treatment of Anogenital Lichen Sclerosus With Topical Tacrolimus

Genital Disease in Children

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