Journal of Cell Biology volume 217, issue 1, P251-268 2017 DOI: 10.1083/jcb.201709111 View full text
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Rajarshi Chakrabarti, Wei-Ke Ji, Radu V. Stan, Jaime de Juan Sanz, Timothy A. Ryan, Henry N. Higgs

Abstract: Actin polymerization through the ER-bound formin INF2 stimulates mitochondrial division by promoting Drp1 recruitment. Chakrabarti et al. extend this work to show that INF2-mediated actin polymerization stimulates a second mitochondrial response independent of Drp1: increased ER–mitochondrial calcium transfer via MCU and inner mitochondrial membrane constriction, which requires electron transport chain activity.