Rajarshi Chakrabarti, Wei-Ke Ji, Radu V. Stan, Jaime de Juan Sanz, Timothy A. Ryan, Henry N. Higgs
Abstract:Actin polymerization through the ER-bound formin INF2 stimulates mitochondrial division by promoting Drp1 recruitment. Chakrabarti et al. extend this work to show that INF2-mediated actin polymerization stimulates a second mitochondrial response independent of Drp1: increased ER–mitochondrial calcium transfer via MCU and inner mitochondrial membrane constriction, which requires electron transport chain activity.
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