Inertial particle focusing dynamics in a trapezoidal straight microchannel: application to particle filtration

Moloudi, Reza; Oh, Steve Kah‐Weng; Yang, Chun; Warkiani, Majid Ebrahimi; Naing, May Win

doi:10.1007/s10404-018-2045-5

Cited by 44 publications

(25 citation statements)

References 63 publications

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“…Thus, one of the possible approaches to improve inertial separation with straight channels is the employment of the channels with an asymmetrical cross-section. For instance, Moloudi et al investigated the possibility of particle separation in a trapezoidal straight microchannel [310]. They figured out that size-dependent particle separation could be effectively controlled by the slope of the channel wall and the speed of the carrying fluid.…”

Section: Inertial Focusing In Microfluidic Channelsmentioning

confidence: 99%

Detection of Rare Objects by Flow Cytometry: Imaging, Cell Sorting, and Deep Learning Approaches

Voronin

Kozlova

Verkhovskii

et al. 2020

IJMS

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Flow cytometry nowadays is among the main working instruments in modern biology paving the way for clinics to provide early, quick, and reliable diagnostics of many blood-related diseases. The major problem for clinical applications is the detection of rare pathogenic objects in patient blood. These objects can be circulating tumor cells, very rare during the early stages of cancer development, various microorganisms and parasites in the blood during acute blood infections. All of these rare diagnostic objects can be detected and identified very rapidly to save a patient’s life. This review outlines the main techniques of visualization of rare objects in the blood flow, methods for extraction of such objects from the blood flow for further investigations and new approaches to identify the objects automatically with the modern deep learning methods.

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Section: Inertial Focusing In Microfluidic Channelsmentioning

confidence: 99%

Detection of Rare Objects by Flow Cytometry: Imaging, Cell Sorting, and Deep Learning Approaches

Voronin

Kozlova

Verkhovskii

et al. 2020

IJMS

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show abstract

“…Instead, these methods depend on the inherent differences of the samples (e.g., size, shape, compressibility). Samples can be sorted by using inertial force , hydrodynamic spreading , filtration , and deterministic lateral displacement . Passive sorting does not require bulky and costly equipments such as power amplifiers or pressure controllers, which makes them easily integrated into a portable device.…”

Section: Flow Control In Microfluidic Flow Cytometrymentioning

confidence: 99%

New advances in microfluidic flow cytometry

Gong

Fan

et al. 2018

Electrophoresis

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In recent years, researchers are paying the increasing attention to the development of portable microfluidic diagnostic devices including microfluidic flow cytometry for the point‐of‐care testing. Microfluidic flow cytometry, where microfluidics and flow cytometry work together to realize novel functionalities on the microchip, provides a powerful tool for measuring the multiple characteristics of biological samples. The development of a portable, low‐cost, and compact flow cytometer can benefit the health care in underserved areas such as Africa or Asia. In this article, we review recent advancements of microfluidics including sample pumping, focusing and sorting, novel detection approaches, and data analysis in the field of flow cytometry. The challenge of microfluidic flow cytometry is also examined briefly.

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“…Size-based microparticle separation has drawn a lot of interest due to its applications in biomedical and biological research. [1][2][3][4][5][6] Conventional separation techniques such as centrifugation, ltration, and sedimentation are associated with wearing and clogging, which affect their efficiency and reliability. 7 Processing biological samples through micro-uidic devices like focusing, 8 on-chip labelling, 9 separation, 10,11 mixing 12,13 and diagnostics 10 is an area of high relevance to the life science community.…”

Section: Introductionmentioning

confidence: 99%

Sheath-less high throughput inertial separation of small microparticles in spiral microchannels with trapezoidal cross-section

2019

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Inertial particle focusing dynamics in a trapezoidal straight microchannel: application to particle filtration

Cited by 44 publications

References 63 publications

Detection of Rare Objects by Flow Cytometry: Imaging, Cell Sorting, and Deep Learning Approaches

Detection of Rare Objects by Flow Cytometry: Imaging, Cell Sorting, and Deep Learning Approaches

New advances in microfluidic flow cytometry

Sheath-less high throughput inertial separation of small microparticles in spiral microchannels with trapezoidal cross-section

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