Industrial, not fruit fructose intake is associated with the severity of liver fibrosis in genotype 1 chronic hepatitis C patients

Petta, Salvatore; Marchesini, Giulio; Caracausi, L.; Macaluso, Fabio Salvatore; Cammà, Calogero; Ciminnisi, Stefania; Cabibi, Daniela; Porcasi, Rossana; Craxı̀, Antonio; Marco, Vito Di

doi:10.1016/j.jhep.2013.07.037

Cited by 33 publications

(30 citation statements)

References 38 publications

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“…Of the 41 potentially relevant fulltext articles, 27 were excluded on the basis of study eligibility criteria, including 4 single-arm trials, [16][17][18][19] 5 case-control studies, [20][21][22][23][24] and 4 cross-sectional studies. [25][26][27][28] No prospective observational studies were identified. Two RCTs 29,30 comparing the potential effect of sucrose with that of isomaltulose (a disaccharide similar to sucrose but with a lower hydrolysis rate) on VAT fat deposition was excluded since isomaltulose is rarely consumed as added sugar anywhere in the world.…”

Section: Resultsmentioning

confidence: 99%

Potential link between excess added sugar intake and ectopic fat: a systematic review of randomized controlled trials

Karlsen

Chung

et al. 2015

Nutr Rev

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Context: The effect of added sugar intake on ectopic fat accumulation is a subject of debate. Objective: A systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to examine the potential effect of added sugar intake on ectopic fat depots. Data Sources: MEDLINE, CAB Abstracts, CAB Global Health, and EBM (Evidence-Based Medicine) Reviews -Cochrane Central Register of Controlled Trials databases were searched for studies published from 1973 to September 2014. Data Extraction: RCTs with a minimum of 6 days' duration of added sugar exposure in the intervention group were selected. The dosage of added sugar intake as a percentage of total energy was extracted or calculated. Means and standard deviations of pre-and post-test measurements or changes in ectopic fat depots were collected. Data Synthesis: Fourteen RCTs were included. Most of the studies had a medium to high risk of bias. Meta-analysis showed that, compared with eucaloric controls, subjects who consumed added sugar under hypercaloric conditions likely increased ectopic fat, particularly in the liver (pooled standardized mean difference ¼ 0.9 [95%CI, 0.6-1.2], n ¼ 6) and muscles (pooled SMD ¼ 0.6 [95%CI, 0.2-1.0], n ¼ 4). No significant difference was observed in liver fat, visceral adipose tissue, or muscle fat when isocaloric intakes of different sources of added sugars were compared. Conclusions: Data from a limited number of RCTs suggest that excess added sugar intake under hypercaloric diet conditions likely increases ectopic fat depots, particularly in the liver and in muscle fat. There are insufficient data to compare the effect of different sources of added sugars on ectopic fat deposition or to compare intake of added sugar with intakes of other macronutrients. Future well-designed RCTs with sufficient power and duration are needed to address the role of sugars on ectopic fat deposition.

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Section: Resultsmentioning

confidence: 99%

Potential link between excess added sugar intake and ectopic fat: a systematic review of randomized controlled trials

Karlsen

Chung

et al. 2015

Nutr Rev

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“…In human NAFLD, fructose is strongly associated with steatohepatitis and liver fibrosis in obese and type 2 diabetes patients [35]. In the livers of mice fed HFHS diet, mRNA encoding SCD2, LPL and CD36 that regulate fatty acid uptake and synthesis in the liver, were upregulated.…”

Section: Discussionmentioning

confidence: 99%

Immunomodulatory liposomes targeting liver macrophages arrest progression of nonalcoholic steatohepatitis

et al. 2018

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, Immunomodulatory liposomes targeting liver macrophages arrest progression of nonalcoholic steatohepatitis, Metabolism (2017Metabolism ( ), doi: 10.1016Metabolism ( /j.metabol.2017 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT ConclusionsLiposomes are a new strategy to target lipid rich inflammatory dendritic cells and have potential to deliver immunomodulatory compounds to treat NASH.

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“…Abdelmalek et al studied the histological severity of NAFLD according to daily fructose intake in a large cohort of adults: although the steatosis grade was lower in those with increased fructose intake, the degree of fibrosis was higher [115]. The daily intake of industrial, not fruit, fructose is a risk factor for severe liver fibrosis, at least in patients with chronic hepatitis C (CHC) [116].…”

Section: Nutritionmentioning

confidence: 99%

A “systems medicine” approach to the study of non-alcoholic fatty liver disease

Petta

Valenti

Bugianesi

et al. 2016

Digestive and Liver Disease

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The prevalence of fatty liver (steatosis) in the general population is rapidly increasing worldwide. The progress of knowledge in the physiopathology of fatty liver is based on the systems biology approach to studying the complex interactions among different physiological systems. Similarly, translational and clinical research should address the complex interplay between these systems impacting on fatty liver. The clinical needs drive the applications of systems medicine to re-define clinical phenotypes, assessing the multiple nature of disease susceptibility and progression (e.g. the definition of risk, prognosis, diagnosis criteria, and new endpoints of clinical trials). Based on this premise and in light of recent findings, the complex mechanisms involved in the pathology of fatty liver and their impact on the short- and long-term clinical outcomes of cardiovascular, metabolic liver diseases associated with steatosis are presented in this review using a new "systems medicine" approach. A new data set is proposed for studying the impairments of different physiological systems that have an impact on fatty liver in different subsets of subjects and patients.

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Industrial, not fruit fructose intake is associated with the severity of liver fibrosis in genotype 1 chronic hepatitis C patients

Cited by 33 publications

References 38 publications

Potential link between excess added sugar intake and ectopic fat: a systematic review of randomized controlled trials

Potential link between excess added sugar intake and ectopic fat: a systematic review of randomized controlled trials

Immunomodulatory liposomes targeting liver macrophages arrest progression of nonalcoholic steatohepatitis

A “systems medicine” approach to the study of non-alcoholic fatty liver disease

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