Inductively coupled plasma mass spectrometry in separation techniques: Recent trends in phosphorus speciation

Shah, Monika; Caruso, Joseph A.

doi:10.1002/jssc.200500234

Cited by 42 publications

(37 citation statements)

References 71 publications

(86 reference statements)

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“…This review will focus only on the identification of seleno-/phospho-/metallo-proteins, structure-function relationships of metalloproteins and clinically used metallodrugs, as well as the discussion of the relevant analytical approaches. Readers are referred to some other excellent reviews in this field, either general (e.g., Haraguchi [22] , Łobinśki et al [21,27] , Sun et al [28] , Chance et al [23] , Szpunar [20] , Bettmer [25] , López-Barea and Gómez-Ariza [29] ) or method-oriented (e.g., Łobinśki et al [10,17] , Shah and Caruso [18] , Aebersold and Mann [16] , Szpunar [30] , Chance et al [31] , Gao et al [32] , Prange and Pröfrock [33] ).…”

Section: Introductionmentioning

confidence: 99%

“…The former produces complete genome DNA sequences for a living organism, whereas the latter aims to study the localization, structure, function and interactions of the complete set of proteins produced in a cell, tissue or organism [15] . Recent developments in highthroughput sample separation, and especially soft ionization mass spectrometry techniques, have made major contributions to the proteomic characterization of proteins in system biology [16][17][18] .…”

Section: Introductionmentioning

confidence: 99%

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Metallomics: An integrated biometal science

Sun

2009

Sci. China Ser. B-Chem.

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Metallomics is an emerging scientific area integrating the research fields related to the understanding of the molecular mechanisms of metal-associated life processes and the entirety of metal and metalloid species within a cell or tissue type. In metallomics, metalloproteins, metalloenzymes and other metalcontaining biomolecules in a biological system are referred to as metallomes, similar to genomes and proteomes in genomics and proteomics, respectively. This review discusses the concept of metallomics with a focus on analytical techniques and methods, particularly the so-called hyphenated techniques which combine a high-resolution separation technique (gel electrophoresis/laser ablation, chromatography or capillary electrophoresis) with a highly sensitive detection method such as elemental (inductively coupled plasma, ICP) or molecular (electron spray ionization (ESI) or matrix-assisted laser desorption/ionization (MALDI)) mass spectrometry, or nuclear X-ray fluorescence/ absorption spectrometry. The applications of these advanced analytical methods in the identification of metallo-/phospho-/seleno-proteins, probing of relationships between structure and function of metalloproteins, and study of clinically used metallodrugs will be selectively outlined, along with their advantages and limitations. metallomics, metallome, metallodrug, metalloprotein, chemical speciation

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Metallomics: An integrated biometal science

Sun

2009

Sci. China Ser. B-Chem.

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“…Caruso et al [41] emphasized hyphenated CE techniques in use for speciation analysis in the assessment of metal toxicity. Other examples of manuscripts published to cover various aspects of CE speciation analysis with ICP-MS detection present an issue by Uden et al [35] on selective detection and identification of selenium-containing compounds and an in-depth review paper by Shah and Caruso [38] on phosphorus speciation. CE methods are increasingly of value in bioinorganic speciation analysis, and recent progress in using ICP-MS and ESI-MS as detectors applied to the emerging areas of metalloproteomics and metallomics was a part of an extensive literature treatment by Szpunar [4].…”

Section: Reviewsmentioning

confidence: 98%

Recent trends in CE of inorganic ions: From individual to multiple elemental species analysis

Timerbaev

2007

Electrophoresis

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The major methodological developments in CE related to inorganic analysis are overviewed. This is an update to a previous review article by the author (Timerbaev, A. R., Electrophoresis 2004, 25, 4008-4031) and it covers the review work and innovative research papers published between January 2004 and the first part of 2006. As was underlined in that review, a growing interest of analytical community in providing elemental speciation information found a sound response of the CE method developers. Presently, almost every second research paper in the field of interest deals with element species analysis, the use of inductively coupled plasma MS detection and biochemical applications being the topics of utmost research efforts. On the other hand, advances in general methodology traditionally centered on a CE system modernization for improvements in sensitivity and separation selectivity have attracted less attention over the review period. While there is no indication that inorganic ion applications would surpass by the developmental rate the more matured analysis of organic analytes, CE can now be seen as an analytical technique to be before long customary in a number of inorganic analysis arenas.

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“…Quantitation of adefovir/Hp/Hb conjugates in biological matrices could be also carried out with high specificity and sensitivity using Ga as a tag by introducing a slight modification to the procedure described in the present work. In this case, Ga/adefovir ratio can be determined by measuring the Ga/P ratio in the conjugate sample by ICP MS (despite interferences from [58], ICP MS allows phosphorus to be monitored with a detection limit in the sub-ppb range [59]). Lastly, the sensitivity of detection and quantitation of exogenous Hp or Hp/ drug conjugates based on metal tags may be further improved by exploring the utility of other metals beyond gallium, since protoporphyrin IX can be substituted with a variety of nonferric metals [60].…”

Section: Icp-ms Detection Of Hp·hb Ga In Human Serummentioning

confidence: 99%

Evaluation of Gallium as a Tracer of Exogenous Hemoglobin–Haptoglobin Complexes for Targeted Drug Delivery Applications

Kaltashov

2016

J. Am. Soc. Mass Spectrom.

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Abstract. Haptoglobin (Hp) is a plasma glycoprotein that generates significant interest in the drug delivery community because of its potential for delivery of antiretroviral medicines with high selectivity to macrophages and monocytes, the latent reservoirs of human immunodeficiency virus. As is the case with other therapies that exploit transport networks for targeted drug delivery, the success of the design and optimization of Hp-based therapies will critically depend on the ability to accurately localize and quantitate Hp-drug conjugates on the varying and unpredictable background of endogenous proteins having identical structure. In this work, we introduce a new strategy for detecting and quantitating exogenous Hp and Hp-based drugs with high sensitivity in complex biological samples using gallium as a tracer of this protein and inductively coupled plasma mass spectrometry (ICP MS) as a method of detection. Metal label is introduced by reconstituting hemoglobin (Hb) with gallium(III)-protoporphyrin IX followed by its complexation with Hp. Formation of the Hp/Hb assembly and its stability are evaluated with native electrospray ionization mass spectrometry. Both stable isotopes of Ga give rise to an abundant signal in ICP MS of a human plasma sample spiked with the metallabeled Hp/Hb complex. The metal label signal exceeds the spectral interferences' contributions by more than an order of magnitude even with the concentration of the exogenous protein below 10 nM, the level that is more than adequate for the planned pharmacokinetic studies of Hp-based therapeutics.

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Inductively coupled plasma mass spectrometry in separation techniques: Recent trends in phosphorus speciation

Cited by 42 publications

References 71 publications

Metallomics: An integrated biometal science

Metallomics: An integrated biometal science

Recent trends in CE of inorganic ions: From individual to multiple elemental species analysis

Evaluation of Gallium as a Tracer of Exogenous Hemoglobin–Haptoglobin Complexes for Targeted Drug Delivery Applications

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