Induction Strategy for Locally Advanced Thymoma

Zhang, Yang; Li, Zongjuan; Chen, Yixing; Tan, Liang; Zeng, Zhao‐Chong; Ding, Jianyong; Du, Shisuo

doi:10.3389/fonc.2021.704220

Cited by 8 publications

(4 citation statements)

References 74 publications

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“…This allows for downstaging of the tumor and may improve the likelihood that the tumor can be resected with negative microscopic margins. However, previous studies have demonstrated that when feasible, initial surgery provides better progression-free and overall survival [ 4 ], and chemotherapy regimens and response rates are highly variable [ 3 , 5 ]. Thus, when amenable, surgery is still recommended as first line, even in cases as ours that may require more invasive techniques [ 1 ].…”

Section: Discussionmentioning

confidence: 99%

Invasive type B2 thymoma associated with myasthenia gravis, resection with superior vena cava reconstruction

Wilde

Carroway

Hsu

et al. 2022

Journal of Surgical Case Reports

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After being diagnosed with myasthenia gravis, a 55-year-old male was referred for treatment of an invasive thymoma. Preoperative imaging revealed a thymoma adjacent to the superior vena cava (SVC) with possible invasion of the left innominate vein. After multidisciplinary discussion, he underwent upfront en bloc resection of the tumor with SVC resection and reconstruction. He was discharged after an uncomplicated postoperative course with improvement of his symptoms.

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Section: Discussionmentioning

confidence: 99%

Invasive type B2 thymoma associated with myasthenia gravis, resection with superior vena cava reconstruction

Wilde

Carroway

Hsu

et al. 2022

Journal of Surgical Case Reports

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“…Chemotherapy alone is the only recommended treatment for metastatic thymomas that are not surgically resectable and not amenable to radiotherapy (stage IV), but it does not benefit stage III–IV completely resected thymomas or thymic carcinomas [ 64 , 65 ]. Advanced or metastatic thymoma and thymic carcinoma can be treated with platinum-based combination chemotherapy, which can shrink the tumor and relieve tumor-related symptoms; however, whether it can prolong survival remains to be determined, but some clinical trials are underway [ 66 ].…”

Section: The Role Of a Multidisciplinary Team In Surgical Decision Ma...mentioning

confidence: 99%

Thymoma and Thymic Carcinoma: Surgical Resection and Multidisciplinary Treatment

Zhang

Lin

Aramini

et al. 2023

Cancers

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Thymoma and thymic carcinoma are the most common tumors of the anterior mediastinum and a relatively rare type of thoracic cancer. The prerequisite for surgery is clinical staging and operative evaluation, both of which are based on medical imaging. The best strategy for treating a thymic epithelial tumor is surgical resection of the organ and surrounding tissue. Thymectomy modalities vary, including open surgery and minimally invasive surgery, and surgeons have used various innovations to better meet the needs of the procedure; therefore, it is critical to select the appropriate procedure based on the patient’s characteristics. Evaluation of resectability is the first step of surgical resection for thymic tumors without distant metastasis. The decision regarding unresectability should be made carefully. During subsequent chemotherapy or chemoradiotherapy, reevaluation of whether an area is resectable or not remains essential. Despite numerous technological advances in the surgical treatment of thymic tumors, several contentious issues remain, including the selection of surgical approaches for difficult cases, the selection of video-assisted thoracoscopic approaches, the evaluation of resectability, minimally invasive surgery for locally advanced thymic tumors, lymphadenectomy in thymic tumors, neoadjuvant therapy for thymic tumors, debulking surgery, and salvage surgery. In solving these problems, the surgeon’s judgment, surgical experience, and surgical skills are especially important.

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“…It is still unclear whether a good pathological response to chemotherapy leads to a good thymoma prognosis like other thoracic cancers. However, substantial necrosis of the tumor was reported in about half of thymoma patients who received induction treatment [ 5 , 6 ]. No such effect of chemotherapy was observed in the resected specimen from our patient.…”

Section: Case Presentationmentioning

confidence: 99%

Type A thymoma: a rare cause of neoplastic cardiac tamponade with long-term survival

et al. 2022

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Background The prognosis of thymoma with cardiac tamponade is generally poor. Most of the reported thymomas with cardiac tamponade were type B or type AB (mixed thymoma), and cardiac tamponade due to type A thymoma, which has a better prognosis compared to type B thymoma, is extremely rare. Case presentation We encountered a case of cardiac tamponade in a 71-year-old male. He visited our emergency department due to exacerbation of fatigue and dyspnea on exertion that lasted for two weeks. Chest imaging revealed a large amount of pericardial fluid and a contrast-enhanced tumor with calcification in the anterior mediastinum. The patient underwent thoracoscopic tumor biopsy and pathological examinations revealed type A thymoma. In this case, long-term disease-free survival (7.5 years) was achieved by multidisciplinary treatment (preoperative chemotherapy, surgical excision, and postoperative radiation therapy), in accordance with the histological type. Conclusions This case indicates that neoplastic cardiac tamponade, even in elderly patients, should not necessarily be regarded as a terminal cancer and requires a systematic investigation for underlying causes.

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Induction Strategy for Locally Advanced Thymoma

Cited by 8 publications

References 74 publications

Invasive type B2 thymoma associated with myasthenia gravis, resection with superior vena cava reconstruction

Invasive type B2 thymoma associated with myasthenia gravis, resection with superior vena cava reconstruction

Thymoma and Thymic Carcinoma: Surgical Resection and Multidisciplinary Treatment

Type A thymoma: a rare cause of neoplastic cardiac tamponade with long-term survival

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