2018
DOI: 10.18632/aging.101404
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Abstract: Aging involves tissue accumulation of senescent cells (SC) whose elimination through senolytic approaches may evoke organismal rejuvenation. SC also contribute to aging-associated pathologies including cancer, hence it is imperative to better identify and target SC. Here, we aimed to identify new cell-surface proteins differentially expressed on human SC. Besides previously reported proteins enriched on SC, we identified 78 proteins enriched and 73 proteins underrepresented in replicatively senescent BJ fibrob… Show more

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Cited by 8 publications
(5 citation statements)
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References 94 publications
(108 reference statements)
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“…Considering the predictive role of the L1CAM and systemic immune-inflammation biomarkers based on the CBC test in the therapeutic efficacy and prognosis in the context of multiple cancers such as lung cancer ( 28 , 34 ), colorectal cancer ( 49 , 50 ), and brain metastases ( 16 , 27 , 51 ), the dynamic quantification of the L1CAM in serum and systemic immune-inflammation biomarkers may act as potentially predictive biomarkers for cancer therapy such as radiation and help to guide patient stratification and treatment decisions, especially when accumulating evidence has shown that both the L1CAM and its strong agonist TGF-β can be induced by radiation ( 1 , 52 , 53 ). We know that the impact of radiation on the immune system is highly heterogenous, which can induce remodeling of systemic immunity either impeding or augmenting overall treatment efficacy and make it challenging to understand the assembling impact on the systemic immune.…”
Section: Discussionmentioning
confidence: 99%
“…Considering the predictive role of the L1CAM and systemic immune-inflammation biomarkers based on the CBC test in the therapeutic efficacy and prognosis in the context of multiple cancers such as lung cancer ( 28 , 34 ), colorectal cancer ( 49 , 50 ), and brain metastases ( 16 , 27 , 51 ), the dynamic quantification of the L1CAM in serum and systemic immune-inflammation biomarkers may act as potentially predictive biomarkers for cancer therapy such as radiation and help to guide patient stratification and treatment decisions, especially when accumulating evidence has shown that both the L1CAM and its strong agonist TGF-β can be induced by radiation ( 1 , 52 , 53 ). We know that the impact of radiation on the immune system is highly heterogenous, which can induce remodeling of systemic immunity either impeding or augmenting overall treatment efficacy and make it challenging to understand the assembling impact on the systemic immune.…”
Section: Discussionmentioning
confidence: 99%
“…64 Also, L1 acts in DNA repair, 68 is linked to hypogonadism, 69 and is involved in aging. 9,[70][71][72] In addition, the association of L1 with testicular germ cell tumors, 73 where HP1 functions, may indicate that L1 is needed for germ cells to develop normally. In the present study, we show that the functional interplay of L1 and HP1 isoforms, which could influence other interaction partners, contributes to the diverse regulation of L1-and HP1-mediated cellular functions, such as proliferation.…”
Section: Discussionmentioning
confidence: 99%
“…In L1‐deficient mice, the size of the corpus callosum is reduced and callosal axons fail to cross the midline, 67 indicating that L1 contributes to the guidance of callosal axons 64 . Also, L1 acts in DNA repair, 68 is linked to hypogonadism, 69 and is involved in aging 9,70–72 . In addition, the association of L1 with testicular germ cell tumors, 73 where HP1 functions, may indicate that L1 is needed for germ cells to develop normally.…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, as suggested by Shi et al (2016), tau proteins reside explicitly within L1CAM expressing exosomes in human plasma, via which toxic tau aggregates are transported from cell to cell contributing to the formation of tauopathies according to a hypothesis. To mention its relation to senescence, L1CAM is stated to be enriched on the surface of senescent fibroblasts and aid their migration (Mrazkova et al, 2018). Another cell adhesion molecule, CLDN19, encodes a tight junction protein (Perdomo-Ramirez et al, 2019).…”
Section: Discussionmentioning
confidence: 99%