Induction of Rosaceiform Dermatitis During Treatment of Facial Inflammatory Dermatoses With Tacrolimus Ointment

Antille, Christophe; Saurat, Jean‐Hilaire; Lübbe, Jann

doi:10.1001/archderm.140.4.457

Cited by 97 publications

(65 citation statements)

References 11 publications

(12 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Among skin lesions, erythema and papules were most commonly observed in TIRD, STRD, and SIRD patients. Finally, pustules were often observed in SIRD patients, but were rarely observed in TIRD and STRD patients, though pustules were previously reported in TIRD patients [6,8]. Thus, our results suggest that there may be some clinical differences between TIRD and SIRD.…”

Section: Discussionsupporting

confidence: 43%

“…RD mostly occurs in women aged 40–50 years and usually results from prolonged or improper use of topical steroids, although it may have many other causes including hormonal factors, heat, ultraviolet light, skin care creams, and continual irritation. Recent studies have reported that continuous use of topical calcineurin inhibitors such as tacrolimus and pimecrolimus may also induce RD [4,5,6,7,8]; however, the epidemiology of calcineurin inhibitor-induced RD is not clear.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Tacrolimus-Induced Rosacea-Like Dermatitis: A Clinical Analysis of 16 Cases Associated with Tacrolimus Ointment Application

Teraki¹,

Hitomi²,

Sato³

et al. 2012

Dermatology

View full text Add to dashboard Cite

Background: Recently, reports have indicated that the continuous use of topical calcineurin inhibitors such as tacrolimus may induce rosacea-like dermatitis (RD). Objective and Methods: To assess clinical features of RD associated with tacrolimus, 44 cases of patients diagnosed with RD between 2005 and 2010 at our hospital were retrospectively reviewed. Results: In total, 22 cases were caused by topical steroid use, 8 by topical tacrolimus use, and 8 by consecutive treatment with topical steroids and tacrolimus. Clinical presentation was basically similar among the 3 groups, although the nose was less frequently affected and pustules were rarely observed in the latter 2 sets of cases. Demodex mites were often found in smears of skin lesions from patients with RD caused by steroids and tacrolimus. Treatment with topical metronidazole was effective in most RD patients. Conclusion: Topical tacrolimus is becoming an important cause of RD along with topical steroids.

show abstract

Section: Discussionsupporting

confidence: 43%

Section: Introductionmentioning

confidence: 99%

Tacrolimus-Induced Rosacea-Like Dermatitis: A Clinical Analysis of 16 Cases Associated with Tacrolimus Ointment Application

Teraki¹,

Hitomi²,

Sato³

et al. 2012

Dermatology

View full text Add to dashboard Cite

show abstract

“…The theory has its roots in the fact that clinical improvement was noted in patients with rosacea who were administered tetracycline antibiotics, although these antibiotics neither demonstrate activity against D. folliculorum nor reduce their numbers on the skin. It has been suggested that the beneficial activity of antibiotics was due to their anti-inflammatory properties; however, other anti-inflammatory agents, such as steroids or tacrolimus, intensify the symptoms of rosacea or even induce its development (Antille et al, 2004). The fact that only some drugs proved to be effective in the treatment of rosacea suggested that that an unknown bacterium may have a role in the pathogenesis of the disease.…”

Section: Potential Role Of Bacillus Oleronius In Rosaceamentioning

confidence: 99%

Potential role of Demodex mites and bacteria in the induction of rosacea

Jarmuda

O'Reilly

Żaba

et al. 2012

Journal of Medical Microbiology

161

111

View full text Add to dashboard Cite

Rosacea is a common dermatological condition that predominantly affects the central regions of the face. Rosacea affects up to 3 % of the world's population and a number of subtypes are recognized. Rosacea can be treated with a variety of antibiotics (e.g. tetracycline or metronidazole) yet no role for bacteria or microbes in its aetiology has been conclusively established. The density of Demodex mites in the skin of rosacea patients is higher than in controls, suggesting a possible role for these mites in the induction of this condition. In addition, Bacillus oleronius, known to be sensitive to the antibiotics used to treat rosacea, has been isolated from a Demodex mite from a patient with papulopustular rosacea and a potential role for this bacterium in the induction of rosacea has been proposed. Staphylococcus epidermidis has been isolated predominantly from the pustules of rosacea patients but not from unaffected skin and may be transported around the face by Demodex mites. These findings raise the possibility that rosacea is fundamentally a bacterial disease resulting from the over-proliferation of Demodex mites living in skin damaged as a result of adverse weathering, age or the production of sebum with an altered fatty acid content. This review surveys the literature relating to the role of Demodex mites and their associated bacteria in the induction and persistence of rosacea and highlights possible therapeutic options.

show abstract

“…(3) shows a peri-ocular scaly erythema during preclinical trial with FK506 eye drops (0.1%) for severe catarrhal conjunctivitis, which was suspicious of allergic contact dermatitis. Also, topical tacrolimus is effective for rosacea, whereas a rosacea-like granulomatous eruption appeared during tacrolimus use [61,62], thus attention should be paid. Although there may be a risk of lymphoma related to topical tacrolimus in animal studies, there are so far no reports of malignancy occurrence during topical tacrolimus use in healthy individuals.…”

Section: Adverse Effects Of Topical Tacrolimus Therapymentioning

confidence: 99%

Topical Tacrolimus for Psoriasis

Yamamoto¹

2009

TOALLJ

View full text Add to dashboard Cite

Tacrolimus ointment is an agent approved for the treatment of atopic dermatitis; however, tacrolimus has been expected also as one of the promising therapeutic strategies for other T-cell mediated inflammatory skin disorders. Recent progress have demonstrated that topical tacrolimus shows beneficial effects for psoriasis depending on sites. In particular, facial, intertriginous, and genital psoriasis respond to topical tacrolimus dramatically in a short period. Further, topical tacrolimus is tolerable also for child psoriasis. Because topical tacrolimus does not induce either skin atrophy or telangiectasia different from corticosteroids, it is recommended to be a first choice. The most proper way of topical tacrolimus therapy at present is to use this ointment intermittently after the remission was once obtained, paying attention to its adverse effects.

show abstract

Induction of Rosaceiform Dermatitis During Treatment of Facial Inflammatory Dermatoses With Tacrolimus Ointment

Cited by 97 publications

References 11 publications

Tacrolimus-Induced Rosacea-Like Dermatitis: A Clinical Analysis of 16 Cases Associated with Tacrolimus Ointment Application

Tacrolimus-Induced Rosacea-Like Dermatitis: A Clinical Analysis of 16 Cases Associated with Tacrolimus Ointment Application

Potential role of Demodex mites and bacteria in the induction of rosacea

Topical Tacrolimus for Psoriasis

Contact Info

Product

Resources

About