volume 93, issue 0, P2-P-177 2020
DOI: 10.1254/jpssuppl.93.0_2-p-177
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Abstract: Background] In pathogenesis of depression, BDNF in the brain play an important role. We found that Shati/Nat8l mRNA is increased in striatum of depression model mice exposed repeated social defeat stress (R-SDS). It is reported that BDNF mRNA levels are increased in any brain regions of Shati/Nat8l KO mice. In this study, we revealed the roles of striatal Shati/Nat8l in depression and mechanism of regulation in BDNF by Shati/Nat8l.[Methods] C57BL/6J mice were exposed R-SDS using ICR mice, and the acetylated hi…

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