Induction of memory-like dendritic cell responses in vivo

Hole, Camaron R.; Wager, Chrissy M. Leopold; Castro-Lopez, Natalia; Campuzano, Althea; Cai, Hong; Wozniak, Karen L.; Wang, Yufeng; Wormley, Floyd L.

doi:10.1038/s41467-019-10486-5

Cited by 131 publications

(115 citation statements)

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“…Recent work has shown that DCs can also show immune memory responses. In this regard, DCs isolated from mice exposed to the fungal pathogen Cryptococcus neoformans displayed strong interferon-γ (IFNγ) production and enhanced proinflammatory cytokine responses on subsequent challenge, which is indicative of a memory response 67 . These effects were dependent on epigenetic changes and were impaired by the treatment of mice with a histone methyltransferase inhibitor 67 .…”

Section: Diversity Of Cells That Can Develop Trained Immunitymentioning

confidence: 99%

Defining trained immunity and its role in health and disease

et al. 2020

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| Immune memory is a defining feature of the acquired immune system, but activation of the innate immune system can also result in enhanced responsiveness to subsequent triggers. This process has been termed 'trained immunity', a de facto innate immune memory. Research in the past decade has pointed to the broad benefits of trained immunity for host defence but has also suggested potentially detrimental outcomes in immune-mediated and chronic inflammatory diseases. Here we define 'trained immunity' as a biological process and discuss the innate stimuli and the epigenetic and metabolic reprogramming events that shape the induction of trained immunity. ✉

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Section: Diversity Of Cells That Can Develop Trained Immunitymentioning

confidence: 99%

Defining trained immunity and its role in health and disease

et al. 2020

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“…There is some evidence that DCs may also have memorylike capabilities. Studies using a vaccine strain of C. neoformans indicate that splenic DCs undergo histone modifications that enhance cytokine responses upon rechallenge with a virulent strain of C. neoformans (Hole et al, 2019). However, these DCs did not have a robust response to other secondary stimuli including LPS, S. aureus, and C. albicans.…”

Section: Trained Immunity: a Second Memory Bank For The Immune Systemmentioning

confidence: 99%

Monocytes and the Host Response to Fungal Pathogens

Heung

2020

Front. Cell. Infect. Microbiol.

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Monocytes and their derivatives, including macrophages and dendritic cells, play diverse roles in the response to fungal pathogens. Sensing of fungi by monocytes triggers signaling pathways that mediate direct effects like phagocytosis and cytokine production. Monocytes can also present fungal antigens to elicit adaptive immune responses. These monocyte-mediated pathways may be either beneficial or harmful to the host. In some instances, fungi have developed mechanisms to evade the consequences of monocyte activation and subvert these cells to promote disease. Thus, monocytes are critically involved in mediating the outcomes of these often highly fatal infections. This review will highlight the roles of monocytes in the immune response to some of the major fungi that cause invasive human disease, including Aspergillus, Cryptococcus, Candida, Histoplasma, Blastomyces, and Coccidioides, and discuss potential strategies to manipulate monocyte responses in order to enhance anti-fungal immunity in susceptible hosts.

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“…Additionally, training of DCs was recently reported. Murine DCs produced more cytokines in response to Cryptococcus neoformans and Staphylococcus aureus 70 days after pulmonary immunization with a recombinant C. neoformans strain expressing IFNγ, in contrast to naïve mice 45 . Two months, but not 2 weeks, after MVA prime and prior to MVA revaccination, we previously showed that blood monocytes, neutrophils, and cDCs were phenotypically "defense-ready".…”

Section: Discussionmentioning

confidence: 91%

Innate and secondary humoral responses are improved by increasing the time between MVA vaccine immunizations

et al. 2020

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Comprehending the mechanisms behind the impact of vaccine regimens on immunity is critical for improving vaccines. Indeed, the time-interval between immunizations may influence B and T cells, as well as innate responses. We compared two vaccine schedules using cynomolgus macaques immunized with an attenuated vaccinia virus. Two subcutaneous injections 2 weeks apart led to an impaired secondary antibody response and similar innate myeloid responses to both immunizations. In contrast, a delayed boost (2 months) improved the quality of the antibody response and involved more activated/mature innate cells, induced late after the prime and responding to the recall. The magnitude and quality of the secondary antibody response correlated with the abundance of these neutrophils, monocytes, and dendritic cells that were modified phenotypically and enriched prior to revaccination at 2 months, but not 2 weeks. These late phenotypic modifications were associated with an enhanced ex vivo cytokine production (including IL-12/23 and IL-1β) by PBMCs short after the second immunization, linking phenotype and functions. This integrated analysis reveals a deep impact of the timing between immunizations, and highlights the importance of early but also late innate responses involving phenotypical changes, in shaping humoral immunity.npj Vaccines (2020) 5:24 ; https://doi.

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Induction of memory-like dendritic cell responses in vivo

Cited by 131 publications

References 50 publications

Defining trained immunity and its role in health and disease

Defining trained immunity and its role in health and disease

Monocytes and the Host Response to Fungal Pathogens

Innate and secondary humoral responses are improved by increasing the time between MVA vaccine immunizations

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