Induction of matrix metalloproteinase-9 secretion from human keratinocytes in culture by ultraviolet B irradiation

Suppression of matrix metalloproteinase-9 expression in undifferentiated, non-apoptotic keratinocytes is abrogated by the cleavage of poly(ADP-ribose) polymerase-1

“…MMP-9, also known as gelatinase B [14,15], plays important roles in various types of tissue metabolism, including tumor invasion and metastasis [19,22,[30][31][32][33], blister formation [21,23], ultraviolet B-induced inflammation [34][35][36], wound healing [37] and angiogenesis [38]. [31].…”

Effects of macelignan isolated from Myristica fragrans Houtt. on UVB-induced matrix metalloproteinase-9 and cyclooxygenase-2 in HaCaT cells

“…Recent studies show that MMP-9 is produced by HaCaT cells when the cells are exposed to UVB above a certain threshold dose. ROS induced by UVB irradiation play a role in the expression of MMPs through the action of redox-regulated transcription factors [36][37][38]. It had been assumed that macelignan's antioxidant properties contributed to this activity because it had been shown in several studies that antioxidants inhibit the activity of UVB-induced MMP-9 [37][38][39].…”

Ultraviolet Light Induced Alteration to the Skin

“…Increased levels of HO-1 may (MMP-1, MMP-2, MMP-3, and MMP-9), whereas UVB generated OH· and LPx induce MMP-1 and MMP-3 and MMP-9 (ref. 8,32 ). The other pathway of UV-induced expression is due to activation of cell-surface receptors with subsequent activation of MAPKs cascade or via expression of inflammatory cytokines 2 .…”