Biochemical Pharmacology volume 80, issue 4, P491-505 2010 DOI: 10.1016/j.bcp.2010.04.025 View full text
In Duk Jung, Jun Sik Lee, Chang-Min Lee, Kyung Tae Noh, Yeong-Il Jeong, Won Sun Park, Sung Hak Chun, Soo Kyung Jeong, Jin Wook Park, Kwang Hee Son, Deok Rim Heo, Min-Goo Lee, Yong Kyoo Shin, Han Wool Kim et al.

Abstract: Heme oxygenase (HO)-1 is expressed in a variety of conditions involved in the regulation of immune responses. In this study, we examined the role of HO-1 in dendritic cell (DC) maturation and expression of indoleamine 2,3-dioxygenase (IDO), a key enzyme that catalyzes the initial, rate-limiting step in tryptophan degradation. IDO deficiency led to diminished phenotypic and functional maturation of DCs in vitro and in vivo. IDO expression and DC maturation was abrogated by the HO inhibitor zinc protoporphrin, b…

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