Induction of glycosuria and hyperglycemia by topical corticosteroid therapy

Abstract

A patient with psoriasis is described who had an abnormal response to the glucose tolerance test without other evidence of diabetes and then developed postprandial hyperglycemia and glycosuria during a period of topical administration of a corticosteroid cream, halcinonide cream 0.1%, under occlusion. A second patient with a similar glucose tolerance test result showed postprandial hyperglycemia when treated similarly with betamethasone valerate cream 0.1%. Two additional patients with midly abnormal responses to glucose tolerance tests showed no evidence of altered glucose metabolism when treated with halcinonide cream in a similar manner.

Psoriasis and Risk of Type 2 Diabetes among Women and Men in the United States: A Population-Based Cohort Study

“…It is worth noting that systemic steroids are not the standard of care for psoriasis in the US and adherence to long-term use of topical steroid is generally low as steroids tend to worsen cutanous manifestations of psoriasis (Brodell and Williams, 1999; Zaghloul and Goodfield, 2004). Hence there is little concern about the gluconeogenic impact of systemic steroid therapy in our study (Gomez and Frost, 1976). It was reported that TNF blocker could have a positive influence on body weight (Saraceno et al, 2008).…”

Pharmacotherapy-Based Problems in the Management of Diabetes Mellitus: Needs Much More to be Done!

“…Insulin and glucocorticoids combination increases hyperglycemia and decreases affinity of tissue receptors response to insulin. [1112] It is noteworthy that thiazide diuretics decreases the sensitivity of insulin to its receptors and of course its secretion as well. [1314] Metformen was prescribed to a renally impaired patient (a contrindications of metformen).…”

“…Hence, we considered the algorithm described by Cantrill and Wood,[7] and Barar[1011] for the management of diabetes as standard protocols.…”

Cutaneous and systemic adverse effect of topical corticosteroids misuse on glucocorticoid dependent women in Iraq.

“…Also, B. Sitte et al observed increased levels of glucose in TCS-treated skin from responders (40). Unfortunately, few studies have been carried out on TCS use causing hyperglycemia (41)(42)(43).…”