Induction of drug photosensitization in man after parenteral exposure to hematoporphyrin

Zalar, G. L.

doi:10.1001/archderm.113.10.1392

Cited by 25 publications

(15 citation statements)

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“…Patients included 17 males and 10 females, with an age range of 2-77 years. Although 24 were Caucasian and three were black, no specific skin type classifications were used.…”

Section: Methodsmentioning

confidence: 99%

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Dihematoporphyrin Ether‐Induced photosensitivity in laryngeal papilloma patients

1990

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Twenty-six patients with recurrent laryngeal papillomatosis received 2.5 mg/kg of Dihematoporphyrin Ether (DHE) intravenously prior to photodynamic therapy. All patients experienced some degree of photosensitivity, the only known side effect of DHE. Reported reactions included mild erythema and inflammation (88%), swelling (58%), blistering (23%), ocular discomfort (61.5%), pruritus (38%), and skin hyperpigmentation (46%). Length of sensitivity ranged from 4-17 weeks, with an average duration of 9 weeks. No long-term debilitating sequelae were noted. Degree of skin reaction mainly depended on how compliant the patient was in following precaution instructions. Although restrictive precautions were often difficult to strictly adhere to, most patients felt the potential benefits of the therapy far outweighed any inconvenience.

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“…Patients included 17 males and 10 females, with an age range of 2-77 years. Although 24 were Caucasian and three were black, no specific skin type classifications were used.…”

Section: Methodsmentioning

confidence: 99%

“…Table 1 discusses some previous reports of photosenstivity reactions following the administration of HPD. [20][21][22][23][24][25] This paper examines the photosensitivity reactions in our patient population and gives a detailed anal-ysis of factors that either affect or prevent this side effect.…”

Section: Introductionmentioning

confidence: 99%

Dihematoporphyrin Ether‐Induced photosensitivity in laryngeal papilloma patients

1990

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“…It is clear that HP causes clinical erythema, oedema and erosion when administered to the skin (Hausmann, 1911;Lipson & Baldes, 1961;Zalar et al, 1977), in addition to degeneration of epidermis, dilatation of vessels and hyperaemia on histopathological examination. (Zalar et al, 1977). P = propionic acid; M = methyl.…”

Section: Oommentioning

confidence: 99%

Lysosome destruction and lipoperoxide formation due to active oxygen generated from haematoporphyrin and UV irradiation

1980

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The lysosomal enzymes, acid-phosphatase and beta-glucuronidase, were released from rat liver lysosome when exposed to 400 nm irradiation in the presence of haematoporphyrin, and the release was prevented by adding vitamin E, diazabicyclo-octane, bovine serum albumin, superoxide dismutase or D-mannitol to the reaction mixture. Monochromatic irradiation with wavelengths from 380 to 410 nm caused no significant differences in the release of lysosomal enzymes, but 420 nm irradiation caused three-fifths of that of 400 nm irradiation. The malondialdehyde level in rat liver homogenate increased after 400 nm irradiation in the presence of haematoporphyrin. Reduction of nitroblue-tetrazolium was not observed when haematoporphyrin was excited by 400 nm; it was considered that superoxide anion radical (O2--) was not primarily generated. The following mechanism was assumed: that porphyrin which had been excited by 400 nm, converted ground-state molecular oxygen (3O2) to excited singlet oxygen (1O2), which formed lipid peroxides in lysosomal membrane resulting in destruction of the membrane; skin changes would occur from these released lysosomal enzymes.

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“…There have been several reports concerning cutaneous changes in the experimental animal or humans administered some kind of porphyrin which provoked an abnormal hyperporphyric condition (13)(14)(15). These experiments are mainly studies of acute changes.…”

Section: Discussionmentioning

confidence: 99%

Induction of Chronic Skin Changes in Intraperitoneally Hematoporphyrin‐Injected Mice with Metal Halide Lamp Irradiation

Honda

Nonaka

Murayama

et al. 1986

The Journal of Dermatology

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To induce chronic skin changes simulating human porphyria, mice which had been injected intraperitoneally with hematoporphyrin dihydrochloride were exposed to metal halide lamps. Clinical and histopathological findings in the mice were observed. Clinically, erythema, edema, erosion, necrosis and crust formation were initially seen in all of the mice treated. Hypertrophy of the skin, scarring, and deformities of the ear lobes followed gradually. Histopathological findings in these skin changes were mainly seen in the dermis and included infiltration of lymphocytes, proliferation of mast cells, dilatation and hyperemia of blood vessels in the upper dermis, and swelling and proliferation of connective tissues. PAS positive materials were deposited in the dermo‐epidermal junction and around the small blood vessels in the upper dermis. Using the direct immunofluorescent technique, the deposition of immunoglobulin G (IgG) was confirmed in the same areas, and some deposition of IgM, IgA and C3 was also observed. These findings are similar to those seen in patients with erythropoietic protoporphyria and porphyria cutanea tarda.

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Induction of drug photosensitization in man after parenteral exposure to hematoporphyrin

Cited by 25 publications

References 0 publications

Dihematoporphyrin Ether‐Induced photosensitivity in laryngeal papilloma patients

Dihematoporphyrin Ether‐Induced photosensitivity in laryngeal papilloma patients

Lysosome destruction and lipoperoxide formation due to active oxygen generated from haematoporphyrin and UV irradiation

Induction of Chronic Skin Changes in Intraperitoneally Hematoporphyrin‐Injected Mice with Metal Halide Lamp Irradiation

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