Induction of collagen synthesis by ascorbic acid. A possible mechanism

Relationships Between Tensile Strength, Ascorbic Acid, Hydroxyproline, and Zinc Levels of Rabbit Full-Thickness Incision Wound Healing

“…This result is similar to the findings of Pinnell and coworkers. 19 Hydroxyproline synthesis, which is upregulated by ascorbic acid in the first 5 days, supports the increase in tensile strength. Between 7 and 15 days after wounding, the ascorbic acid and Zn levels of wound tissue decrease significantly in contrast to the increase in the tensile strength and the unchanged HP level.…”

Ascorbic acid for the healing of skin wounds in rats

“…During all our experiment, collagen fibres were thicker, more organized and parallel to one another in the TG wounds when compared to the CG. AA is a co-factor of lysil and prolyl hydroxylases, two essential enzymes in collagen biosynthesis (Pinnel, Murad and Darr, 1987). Lysil and prolyl hydroxylases are ferric enzymes (Boyera et al, 1998).…”

Effect of Pantothenic Acid and Ascorbic Acid Supplementation on Human Skin Wound Healing Process

“…AA is a cofactor of hydroxylation in the early stages of collagen synthesis [8] and stim ulates collagen-specific mRNA [20]. Indeed, AA enhances in vitro intracellular collagen synthesis, decreases its degradation, and en hances its release out of the cells [3,20].…”

“…Indeed, AA enhances in vitro intracellular collagen synthesis, decreases its degradation, and en hances its release out of the cells [3,20]. AA deficiencies clearly produce alterations of healing processes during scurvy [8].…”