volume 292, issue 1, PG66-G75 2007
DOI: 10.1152/ajpgi.00248.2006
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Abstract: Luteolin is 3Ј,4Ј,5,7-tetrahydroxyflavone found in celery, green pepper, and perilla leaf that inhibits tumorigenesis in animal models. We examined luteolin-mediated regulation of cell cycle progression and apoptosis in the HT-29 human colon cancer cell line. Luteolin decreased DNA synthesis and viable HT-29 cell numbers in a concentrationdependent manner. It inhibited cyclin-dependent kinase (CDK)4 and CDK2 activity, resulting in G 1 arrest with a concomitant decrease of phosphorylation of retinoblastoma pro…

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