Induction of cell cycle arrest and apoptosis in human cervix carcinoma cells during therapy by cisplatin

Synergistic Anticancer Activity of 5-Aminolevulinic Acid Photodynamic Therapy in Combination with Low-dose Cisplatin on Hela Cells

“…However, it has been previously reported that p53 can be reactived upon treatment with cispaltin (Wesierska-Gadek et al, 2002;Schloffer et al, 2003;Liu et al, 2008). In our study, we also observed that expression of p53 protein and its down-stream targets cyclin p21 was upregulated after 5 mg/L cisplatin treatment.…”

Induction of Mitochondrial-Mediated Apoptosis by Morinda Citrifolia (Noni) in Human Cervical Cancer Cells

“…It is a platinum-based compound that forms intra-and inter-strand adducts with DNA, thus it is a potent inducer of cell cycle arrest, and apoptosis in most cancer cell types (Schloffer et al, 2003). However, a major limitation of chemotherapy is that many tumors either are inherently resistant or acquire resistance to the drug after an initial response (Kartalou et al, 2001).…”

Antileukemic effect of zerumbone-loaded nanostructured lipid carrier in WEHI-3B cell-induced murine leukemia model

“…15 The WEHI-3B cells were seeded at a density 1×10 5 cells/mL and incubated for 24 hours. The cells were then treated with 7.5±0.55 µg/mL ZER-NLC for 24 hours, 48 hours, and 72 hours.…”