Induction of Apoptosis in HeLa Cancer Cells by Ultrasonic-mediated Synthesis of Curcumin-loaded Chitosan-alginate-STPP Nanoparticles

Ahmadi, Fatemeh; Kasman, Maryam Ghasemi; Tabari, Maryam Gholamitabar; Kazemi, Sohrab; Ghasemi, Shahram; Pourbagher, Ali Alinejad mirand Roghayeh

doi:10.4172/2157-7439.1000455

Cited by 8 publications

(18 citation statements)

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“…4 Curcumin is a hydrophobic polyphenol that is derived from the rhizomes of the Curcuma longa. 5 It has been well documented that curcumin possesses a wide variety of important pharmacological activities including anticancer, [6][7][8][9] antimicrobial, 10 anti-inflammatory, 11 anti-amyloid, 12,13 antioxidant, 14 and neuroprotective effects. 15 Traditionally, turmeric has been used for several aliments and especially it is widely consumed for dietary and medicinal purposes in Southeast Asia, the China, and India.…”

Section: Introductionmentioning

confidence: 99%

<p>Curcumin-loaded nanoparticles: a novel therapeutic strategy in treatment of central nervous system disorders</p>

Yavarpour-Bali¹,

Ghasemi-Kasman²,

Pirzadeh³

2019

IJN

235

123

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Curcumin as a hydrophobic polyphenol is extracted from the rhizome of Curcuma longa. Curcumin is widely used as a dietary spice and a topical medication for the treatment of inflammatory disorders in Asia. This compound also possesses remarkable anti-inflammatory and neuroprotective effects with the ability to pass from the blood brain barrier. Based on several pharmacological activities of curcumin, it has been introduced as an ideal candidate for different neurological disorders. Despite the pleiotropic activities of curcumin, poor solubility, rapid clearance and low stability have limited its clinical application. In recent years, nano-based drug delivery system has effectively improved the aqueous solubility and bioavailability of curcumin. In this review article, the effects of curcumin nanoparticles and their possible mechanism/s of action has been elucidated in various central nervous system (CNS)-related diseases including Parkinson's disease, Huntington disease, Alzheimer's disease, Multiple sclerosis, epilepsy and Amyotrophic Lateral Sclerosis. Furthermore, recent evidences about administration of nano-curcumin in the clinical trial phase have been described in the present review article.

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Section: Introductionmentioning

confidence: 99%

<p>Curcumin-loaded nanoparticles: a novel therapeutic strategy in treatment of central nervous system disorders</p>

Yavarpour-Bali¹,

Ghasemi-Kasman²,

Pirzadeh³

2019

IJN

235

123

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“…These advantages of alginate and CHI make them promising candidates as nanocarriers for drug delivery [35]. In fact, various alginate or CHI based nanoparticles have been developed for the delivery of CUR [32,[40][41][42][43]. For example, Anitha et al [40] prepared CUR loaded dextran sulphate-chitosan nanoparticles and reported that a controlled and pH dependent CUR release over a period of one week was achieved.…”

Section: Introductionmentioning

confidence: 99%

Magnetic Alginate / Chitosan Nanoparticles for Targeted Delivery of Curcumin into Human Breast Cancer Cells

Song

Gregory

et al. 2018

Preprint

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Curcumin is a promising anti-cancer drug but its applications in cancer therapy are limited due to its poor solubility, short half-life and low bioavailability. In this study, curcumin loaded magnetic alginate / chitosan nanoparticles were fabricated to improve the bioavailability, uptake efficiency and cytotoxicity of curcumin to MDA-MB-231 breast cancer cells. Alginate and chitosan were deposited on Fe3O4 magnetic nanoparticles based on their electrostatic properties. The sizes of the nanoparticles (120-200 nm) were within the optimum range for drug delivery. Sustained curcumin release was obtained use the nanoparticles with the ability to control the curcumin release rate by altering the number of chitosan and alginate layers. Confocal fluorescence microscopy results showed that targeted delivery of curcumin with the aid of magnetic field were achieved. The FACS assay indicated that MDA-MB-231 cells treated with curcumin loaded nanoparticles had a 3-6 folds uptake efficiency to those treated with free curcumin. MTT assay indicated that the curcumin loaded nanoparticles exhibited significantly higher cytotoxicity toward MDA-MB-231 cells than toward HDF cells. The sustained release profiles, enhanced uptake efficiency and cytotoxicity to cancer cells as well as the targeting potential make MACPs a promising candidate for cancer therapy.

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“…59 Folic acid conjugated curcumin-loaded PLGA-PEG NPs (PPF-curcumin) markedly inhibited growth of the tumor in NOD-SCID mice xenografted with cervical cancer cells. 60 PPF-curcumin worked synergistically with paclitaxel and did not show any significant toxicity. These nanoparticles did not induce any significant morphological change or pathological conditions at given dosages.…”

Section: Nanoparticles Assisted Delivery Of Curcuminmentioning

confidence: 88%

“…Liver enzymes were not noted to be fluctuated from their normal ranges which clearly demonstrated that these nanoparticles did not cause any major hepatotoxicity. 60 Glutathione conjugated Polyethylenimine on the surface of Fe3O4 magnetic NPs have also been reported to efficiently carry curcumin. 61 In vivo blood circulation analysis of the nanoparticles also exhibited considerably improved serum bioavailability upto 2.5-fold for curcumin loaded nanoparticles as compared to free curcumin.…”

Section: Nanoparticles Assisted Delivery Of Curcuminmentioning

confidence: 99%

Curcumin on the “flying carpets” to modulate different signal transduction cascades in cancers: Next‐generation approach to bridge translational gaps

Çelik¹,

Aydin²,

Solak

et al. 2018

J of Cellular Biochemistry

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Curcumin, a bioactive and pharmacologically efficient component isolated from Curcuma longa has attracted considerable attention because of its ability to modulate diverse cellular and physiological pathways. WNT, TGF/SMAD, NOTCH, and SHH are fundamentally different signaling cascades, but their choreographed activation is strongly associated with cancer development and progression. In this review we have attempted to set spotlight on regulation of different cell signaling pathways by curcumin in different cancers. We partition this multi-component review into in-depth biological understanding of various signal transduction cascades and how curcumin targets intracellular signal transducers of deregulated pathways to inhibit cancer development and progression. Rapidly broadening landscape of both established and candidate oncogenic driver mutations identified in different cancers is a major stumbling block in the standardization of drugs having significant clinical outcome. Intra and inter-tumor heterogeneity had leveraged the complexity of therapeutic challenges to another level. Multi-pronged approach and molecularly guided treatments will be helpful in improving the clinical outcome.

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Induction of Apoptosis in HeLa Cancer Cells by Ultrasonic-mediated Synthesis of Curcumin-loaded Chitosan-alginate-STPP Nanoparticles

Cited by 8 publications

References 0 publications

<p>Curcumin-loaded nanoparticles: a novel therapeutic strategy in treatment of central nervous system disorders</p>

<p>Curcumin-loaded nanoparticles: a novel therapeutic strategy in treatment of central nervous system disorders</p>

Magnetic Alginate / Chitosan Nanoparticles for Targeted Delivery of Curcumin into Human Breast Cancer Cells

Curcumin on the “flying carpets” to modulate different signal transduction cascades in cancers: Next‐generation approach to bridge translational gaps

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