Induction of Antitumor Response by In Vivo Allogeneic Major Histocompatibility Complex Gene Transfer Using Electroporation

Shimizu, Hiroaki; Nukui, Yuji; Mitsuhashi, Noboru; Kimura, Fumio; Yoshidome, Hiroyuki; Ohtsuka, Masayuki; Kato, Atsushi; Miyazaki, Masaru

doi:10.1016/j.jss.2008.05.035

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“…To keep a sustained GvL, post transplantation, delayed Th2 infusion and allogeneic therapeutic vaccines have a great potential. Similarly in vivo transfer of allogeneic MHC genes [100,69] into tumors can further help in maintaining a threshold GvL. Optimization of this former technique as well as its extension to solid tumors need to be explored.…”

Section: Discussionmentioning

confidence: 99%