J. Neurosci. Res. volume 86, issue 5, P1125-1131 2008 DOI: 10.1002/jnr.21555 View full text
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Jung-Bin Kim, Chae-Moon Lim, Young-Mi Yu, Ja-Kyeong Lee

Abstract: High-mobility group box-1 (HMGB1) was originally identified as a ubiquitously expressed, abundant nonhistone DNA-binding protein. Recently, it was found to act as a cytokine-like mediator of delayed endotoxin lethality and of acute lung injury. Previously, we reported that HMGB1 is massively released extracellularly and plays a cytokine-like function in the postischemic brain. In the present study, we examined the expression profile and cellular distribution of HMGB1 in rat brain after transient focal cerebral…

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