Biochemical Pharmacology volume 79, issue 7, P948-954 2010 DOI: 10.1016/j.bcp.2009.11.004 View full text
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Hui Yang, Nathan Bushue, Pengli Bu, Yu-Jui Yvonne Wan

Abstract: AbstractFenretinide, a synthetic retinoid, is known to induce apoptosis in various cancer cells. However, the mechanism by which fenretinide induces apoptosis remains unclear. The current study examines the mechanisms of fenretinide-induced apoptosis in human hepatoma cells. The induction of Nur77 and the cytoplasmic distribution of Nur77 induced by fenretinide were positively correlated with the apoptotic effect of fenretinide in HCC cells. The sensitivity of Huh-7 cells was related to Nur77 translocation an…

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