volume 192, issue 12, P5776-5788 2014
DOI: 10.4049/jimmunol.1301661
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Dorothée Duluc, HyeMee Joo, Ling Ni, Wenjie Yin, Katherine Upchurch, Dapeng Li, Yaming Xue, Peter Klucar, Sandra Zurawski, Gerard Zurawski, SangKon Oh

Abstract: Recent compelling evidence indicates that Th17 confer host immunity against a variety of microbes, including extracellular and intracellular pathogens. Therefore, understanding mechanisms for the induction and activation of antigen-specific Th17 is important for the rational design of vaccines against pathogens. To study this, we employed an in vitro system in which influenza HA1 was delivered to dendritic cells (DCs) via Dectin-1 using anti-hDectin-1-HA1 recombinant fusion proteins. We found that healthy ind…

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