2020
DOI: 10.3389/fnagi.2020.00149
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Abstract: Recent transcranial magnetic stimulation (TMS) research indicated that the ability of the dorsolateral prefrontal cortex (DLPFC) to disinhibit the contralateral primary motor cortex (M1) during motor preparation is an important predictor for bimanual motor performance in both young and older healthy adults. However, this DLPFC-M1 disinhibition is reduced in older adults. Here, we transiently suppressed left DLPFC using repetitive TMS (rTMS) during a cyclical bimanual task and investigated the effect of left DL… Show more

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Cited by 11 publications
(13 citation statements)
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References 95 publications
(125 reference statements)
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“…Particularly, studies using TMS suggest that brain structures associated with action selection are also involved in regulation of inhibitory projections from prefrontal and premotor regions to M1 (e.g., [ 14 ]). These inhibitory processes are hypothesized to be particularly important during movement preparation than during movement execution (e.g., [ 27 ]). Therefore, it is expected that response errors could offer a more objective assessment of inhibitory control than response time or reaction time.…”
Section: Literature Search and Characteristics Of The Included Stumentioning
confidence: 99%
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“…Particularly, studies using TMS suggest that brain structures associated with action selection are also involved in regulation of inhibitory projections from prefrontal and premotor regions to M1 (e.g., [ 14 ]). These inhibitory processes are hypothesized to be particularly important during movement preparation than during movement execution (e.g., [ 27 ]). Therefore, it is expected that response errors could offer a more objective assessment of inhibitory control than response time or reaction time.…”
Section: Literature Search and Characteristics Of The Included Stumentioning
confidence: 99%
“…For example, two studies [ 14 , 15 ] showed that the magnitude of the release of interhemispheric DLPFC-M1 inhibition (i.e., disinhibition) during visually guided action preparation was associated with better performance of complex bimanual tasks. Further evidence for the involvement of DLPFC in the regulation of movement preparation and movement execution through inhibition/disinhibition of M1 came from recent studies where cortical excitability over the DLPFC was manipulated with repetitive TMS (e.g., [ 4 , 27 ]). Taken together, findings from all included studies using brain imaging methods suggest that acute exercise could improve top-down control of inhibition by increasing activation of prefrontal cortices.…”
Section: Effects On Behavioral and Neurophysiological Aspects Of Imentioning
confidence: 99%
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“…Functional connections between these regions, both within and across hemispheres, are known to be vital for bimanual coordination ( Gerloff and Andres, 2002 ; Solesio-Jofre et al, 2018 ). These functional projections heavily rely upon intracortical and interhemispheric inhibitory processes which are known to decline with advancing age, thereby contributing to degraded motor performance ( Bhandari et al, 2016 ; Fling and Seidler, 2012 ; Fujiyama et al, 2016 ; Levin et al, 2014 ; Verstraelen et al, 2020 ). This body of knowledge predominantly originated from transcranial magnetic stimulation (TMS) studies that provide information on synaptic inhibitory mechanisms mediated by gamma aminobutyric acid (GABA) receptors ( Ziemann et al, 2015 ).…”
Section: Introductionmentioning
confidence: 99%
“…Inclusion of contralateral M1 was intended to serve as a positive control to dissociate the unique contributions of PMA and SMA (further explanation below). Although recent work has shown a role of DLPFC in disinhibiting contralateral M1 during bilateral movement preparation, 42,43 ipsilateral DLPFC was intended to serve as a negative control with an expected negligible effect on unilateral reaching. DLPFC is also involved in working memory, 44 but there was minimal demand to recall target location in the task paradigm described here.…”
Section: Transcranial Magnetic Stimulationmentioning
confidence: 99%