Induced Spasm in the Retinal Arterioles of Cats

Retinal vascular occlusion after vitrectomy with retrobulbar anesthesia–observational case series and survey of literature

“…The best visual acuity prior to the removal of the silicone oil was 20/50; the final visual acuity (1 year after surgery) was 20/200 Table 1) who had undergone uncomplicated vitrectomy with retrobulbar anesthesia for a macular hole using 15% SF 6− gas filling. Occlusion of the retinal artery occurred 2 days after surgery of the central retinal artery [3], in analogy to the finding that stimulation of the retinal arterioles in cats can trigger a vasospasm [6]. During the 3-month time-span of the published findings, 141 patients have undergone vitrectomy in the same context at our own center, the incidence of postoperative vasoocclusive events among these individuals being 4.3% (six patients).…”

Retinal vascular occlusion after vitrectomy with retrobulbar anesthesia–observational case series and survey of literature

“…The best visual acuity prior to the removal of the silicone oil was 20/50; the final visual acuity (1 year after surgery) was 20/200 Table 1) who had undergone uncomplicated vitrectomy with retrobulbar anesthesia for a macular hole using 15% SF 6− gas filling. Occlusion of the retinal artery occurred 2 days after surgery of the central retinal artery [3], in analogy to the finding that stimulation of the retinal arterioles in cats can trigger a vasospasm [6]. During the 3-month time-span of the published findings, 141 patients have undergone vitrectomy in the same context at our own center, the incidence of postoperative vasoocclusive events among these individuals being 4.3% (six patients).…”

Sudden Blindness Secondary to Injections of Common Drugs in the Head and Neck: II. Animal Studies

“…The sudden occurrence of unilateral and bilateral blindness, as reported In the literature from the perso ....al experiences of numerous qualified Investigators, occurring In humans and producing such catastrophic effects seems to mandate experimental effort to try and answer three basic questions: (1) Can an animal model be found which will demonstrate similar retinopathy for studyl (2) If such a model Is found, what mechanisms are Involved In the production of the retinal pathologic changed (3) What are the characteristics of the drug or drug combinations necessary to produce these pathologic changesl…”

Retinal vascular occlusion after vitrectomy with retrobulbar anesthesia–observational case series and survey of literature

“…The best visual acuity prior to the removal of the silicone oil was 20/50; the final visual acuity (1 year after surgery) was 20/200 Table 1) who had undergone uncomplicated vitrectomy with retrobulbar anesthesia for a macular hole using 15% SF 6− gas filling. Occlusion of the retinal artery occurred 2 days after surgery of the central retinal artery [3], in analogy to the finding that stimulation of the retinal arterioles in cats can trigger a vasospasm [6]. During the 3-month time-span of the published findings, 141 patients have undergone vitrectomy in the same context at our own center, the incidence of postoperative vasoocclusive events among these individuals being 4.3% (six patients).…”

Sudden Blindness Secondary to Injections of Common Drugs in the Head and Neck: II. Animal Studies

“…The sudden occurrence of unilateral and bilateral blindness, as reported In the literature from the perso ....al experiences of numerous qualified Investigators, occurring In humans and producing such catastrophic effects seems to mandate experimental effort to try and answer three basic questions: (1) Can an animal model be found which will demonstrate similar retinopathy for studyl (2) If such a model Is found, what mechanisms are Involved In the production of the retinal pathologic changed (3) What are the characteristics of the drug or drug combinations necessary to produce these pathologic changesl…”

Retinal vascular occlusion after vitrectomy with retrobulbar anesthesia–observational case series and survey of literature

“…The best visual acuity prior to the removal of the silicone oil was 20/50; the final visual acuity (1 year after surgery) was 20/200 Table 1) who had undergone uncomplicated vitrectomy with retrobulbar anesthesia for a macular hole using 15% SF 6− gas filling. Occlusion of the retinal artery occurred 2 days after surgery of the central retinal artery [3], in analogy to the finding that stimulation of the retinal arterioles in cats can trigger a vasospasm [6]. During the 3-month time-span of the published findings, 141 patients have undergone vitrectomy in the same context at our own center, the incidence of postoperative vasoocclusive events among these individuals being 4.3% (six patients).…”

Sudden Blindness Secondary to Injections of Common Drugs in the Head and Neck: II. Animal Studies

“…The sudden occurrence of unilateral and bilateral blindness, as reported In the literature from the perso ....al experiences of numerous qualified Investigators, occurring In humans and producing such catastrophic effects seems to mandate experimental effort to try and answer three basic questions: (1) Can an animal model be found which will demonstrate similar retinopathy for studyl (2) If such a model Is found, what mechanisms are Involved In the production of the retinal pathologic changed (3) What are the characteristics of the drug or drug combinations necessary to produce these pathologic changesl…”