Induced Lactation: A Study of 37 Non-puerperal Mothers

Nemba, Kuria

doi:10.1093/tropej/40.4.240

Cited by 35 publications

(55 citation statements)

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“…In fact, mothers breast-feeding their infants do have such short half-lives for TCDD and other PCDDs/PCDFs and polychlorinated biphenyls (Abraham et al 1998). Lactation can be sufficiently induced up to significant levels even in nonpuerperal women, however, may achieve limited success without the motivation of child-nursing (Nemba 1994). As serum lipoproteins bind TCDD (Patterson et al 1989), elimination of TCDD from plasma by LDLapheresis, a method to reduce plasma lipids primarily employed in patients with familial hypercholesterolemia resistant to conventional lipid-lowering therapy (Richter et al 1993;Banyai et al 1998), was considered another option.…”

Section: Discussionmentioning

confidence: 99%

Severe 2,3,7,8-tetrachlorodibenzo- p -dioxin (TCDD) intoxication: kinetics and trials to enhance elimination in two patients

Geusau

Schmaldienst

Derfler

et al. 2002

Archives of Toxicology

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In spring 1998, two women were diagnosed with severe 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) intoxication. Over the following 3 years, TCDD levels were monitored under various attempts to enhance its elimination, and the half-lives were evaluated. Olestra, a non-digestible, non-absorbable dietary fat substitute, was continuously administered to the patients either as pure substance or in potato-chips. Additionally, in the more severely contaminated patient, we studied whether low-density lipoprotein (LDL)-apheresis, an extracorporeal means of blood lipid elimination, was effective in reducing the TCDD body burden. The blood concentrations initially measured in spring 1998 were 144,000 pg/g blood fat in patient 1 and 26,000 pg/g in patient 2, the highest levels ever measured in adults. In March 2001, concentrations in blood fat were 35,900 and 9,500 pg/g, corresponding to overall elimination half-lives of 560 days (1.5 years) in patient 1 and 1050 days (2.9 years) in patient 2, which are considerably shorter than median values of 7-9 years reported for background and moderate exposure levels. Calculations of the TCDD half-lives and measurements of TCDD elimination via different routes allowed the calculation of an unidentified route of elimination, representing 78 and 62% of the overall elimination in patient 1 and 2, respectively, probably due to an induced hepatic metabolism caused by the high TCDD exposure. As previously reported, administration of olestra was found to be effective in increasing the fecal excretion of TCDD. Due to the short half-lives in our patients, the effect of olestra on the overall elimination was relatively small, but is expected to be much greater for 'normal' half-lives. LDL-apheresis was shown to eliminate TCDD, corresponding to the eliminated blood fat. When employed twice a week, the amount of TCDD excreted by this method was comparable to fecal excretion. In view of costs and time involved, LDL-apheresis does not seem to be justified for enhancement of TCDD elimination.

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Section: Discussionmentioning

confidence: 99%

Severe 2,3,7,8-tetrachlorodibenzo- p -dioxin (TCDD) intoxication: kinetics and trials to enhance elimination in two patients

Geusau

Schmaldienst

Derfler

et al. 2002

Archives of Toxicology

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“…Among the reasons which would encourage nursing through the method of induced lactation are: to save the lives of babies whose mothers die soon after their birth (15)(16)(17); to build a strong bond between mothers and the children to whom they did not give birth (18); to meet the nutritional needs for breast milk in the case of babies carried by surrogate mothers (19,20); and nursing an adopted child is to create a restriction against marriage between siblings who were nursed by the same mother (21). Child adoption can raise many conflicts, especially among Muslims with regard to the issue of mahram relationships between adoptive parents and children.…”

Section: Methodsmentioning

confidence: 99%

“…Next, the rounding mechanism for witnessing breastfeeding is divided into two, namely 1) recognition and 2) evidence. In summary, there are many rules and guidelines research, case reports, various websites and a small number of publications indicate that the practice continues today (1,3,5,8,17,(44)(45)(46)(47).…”

Section: Breastfeeding Adopted Children: An Islamic Perspectivementioning

confidence: 99%

“…In addition, there have been several studies conducted on induced lactation practices, such as examining the success of induced lactation in non-pregnant women (17); identifying the processes that promote milk production for women who want to induce lactation (8); exploring motivating factors or reasons for why women want to breastfeed their adopted children (5,48) and gathering experiences of induced lactation (57,58). To date, there is no published data about induced lactation protocols or procedures in Malaysia.…”

Section: Breastfeeding Adopted Children: An Islamic Perspectivementioning

confidence: 99%

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The Availability of Information on Induced Lactation in Malaysia

Rahim

Sulaiman

Ismail

2017

MJMS

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Induced lactation is a method of stimulating the production of breast milk in women who have not gone through the process of pregnancy. Recent advances in technology have given such women the opportunity to breastfeed adopted children. Previous studies conducted in Western countries have explored the breastfeeding of adopted children, as well as the experiences, successes and challenges of this process. However, research on procedures for breastfeeding adopted children is lacking in Malaysia. The authors have therefore reviewed literature related to induced lactation in Malaysia to fill this gap. Of the 30 related articles identified, 19 described the breastfeeding practices and experiences of adoptive mothers in Malaysia. Out of 19 articles, there were four journal articles, five circulars and regulations, two books, two post-graduate theses, four blogs posts and forum discussions, and two online newspaper articles. Medical information relating to induced lactation procedures was also reviewed, showing that there was a lack of scientific studies focusing on induced lactation practices among adoptive mothers. Information on religious, specifically Islamic, perspectives on breastfeeding and child adoption laws was gathered from websites, social networks, blogs, magazines and online news sources. In consideration of recent advancements in medical technology and the dire need among Malaysians, it is crucial that evidence-based, accurate and reliable information on induced lactation is made available to professionals and other individuals in this country.

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“…[4][5][6][7][8][9] Relactation has been reported in nonbiological mothers of adopted children in many cultures and settings around the world. [10][11][12][13] One of the earliest reports is from South Africa noting the practice of older women taking up breastfeeding of their grandchildren. 14 Support for relactation has also been incorporated into nutrition rehabilitation programs for young children who have been weaned [15][16][17] and has been part of programs to support women with lactation difficulties or early weaning.…”

Section: Introductionmentioning

confidence: 99%