Indomethacin polymorphs: Experimental and conformational analysis

A Kinetic Study of the Polymorphic Transformation of Nimodipine and Indomethacin during High Shear Granulation

“…The samples used for the XRPD were also used for the DSC analysis. The melting points and enthalpies of fusion of NMD and IMC are shown in Table II, and these were similar to the reported values (2,21). The peaks of mixed polymorphic forms were completely separated from each other so that they could be quantitatively determined by DSC.…”

Solution thermodynamics of simvastatin in pure solvents and binary solvent mixtures

“…b The number in references represents the provenance of the tested pharmaceuticals. n-heptane were calculated by equation (8). b x 0 2 represents the initial mole fraction of n-heptane in binary solvent mixtures of isobutyl acetate and n-heptane in absence of simvastatin.…”

“…As an important unit operation for production of pharmaceuticals, the crystallization process which is used to purify SMV during its manufacturing will directly determine the quality of the products and the yield of the process. Although solubility data of SMV in a family of alcohols at various temperatures have been reported [8], it has been found that alcohols might not be the ideal solvents for the purification and refinement processes [9] of SMV since some problems such as wide size distribution and poor flowability of products exist.…”

Polymorphism and Solvatomorphism 2009

“…51 The crystal structure of mebendazole Form-C has been reported, which was found to crystallize in the triclinic P-1 space group as a nearly planar molecule with some twisting of the benzoyl group relative to the benzimidazole ring. 52 The properties of three polymorphs of nateglinide were evaluated using a variety of methods, and all three forms were found to bear monotropic relationships to each other.…”