Indocyanine green (ICG) – Menthol loaded cerasomal nanoparticles for ultrasound imaging and photothermal therapy against tumor

Yang, Xi; Wang, Chunan; Ding, Mengli; Zhang, Chunyang; Wang, Wei; Cao, Zhong

doi:10.1016/j.matlet.2019.126524

Cited by 9 publications

(2 citation statements)

References 18 publications

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“…Zuo prepared cryptotanshinone-loaded keratin liposomes for topical use and improved drug's bioavailability in the skin and its anti-acne effect [15]. Yang established indocyanine-green-and L-menthol-loaded hybrid cerasomes as a multifunctional theranostic nanoplatform for US imaging and photothermal therapy [16]. This method utilizes ceramides, cholesterol, palmitic acid, and cholesterol sulfate.…”

Section: Introductionmentioning

confidence: 99%

Mechanisms of Penetration Enhancement and Transport Utilizing Skin Keratine Liposomes for the Topical Delivery of Licochalcone A

Wang

et al. 2022

Molecules

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Keratin liposomes have emerged as a useful topical drug delivery system given theirenhanced ability to penetrate the skin, making them ideal as topical drug vehicles. However, the mechanisms of the drug penetration enhancement of keratin liposomes have not been clearly elucidated. Therefore, licochalcone A(LA)-loaded skin keratin liposomes (LALs) were prepared to investigate their mechanisms of penetration enhancement on the skin and inB16F10 cells. Skin deposition studies, differential scanning calorimetry (DSC), attenuated total reflection-Fourier Transform Infrared Spectroscopy (ATR-FTIR), and skin distribution and intracellular distribution studies were carried out to demonstrate the drug enhancement mechanisms of LALs. We found that the optimal application of LALs enhanced drug permeation via alterations in the components, structure, and thermodynamic properties of the stratum corneum (SC), that is, by enhancing the lipid fluidization, altering the skin keratin, and changing the thermodynamic properties of the SC. Moreover, hair follicles were the main penetration pathways for the LA delivery, which occurred in a time-dependent manner. In the B16F10 cells, the skin keratin liposomes effectively delivered LA into the cytoplasm without cytotoxicity. Thus, LAL nanoparticles are promising topical drug delivery systems for pharmaceutical and cosmetic applications.

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Section: Introductionmentioning

confidence: 99%

Mechanisms of Penetration Enhancement and Transport Utilizing Skin Keratine Liposomes for the Topical Delivery of Licochalcone A

Wang

et al. 2022

Molecules

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“…Fluorescent organic molecules are already used for bioimaging and show advantages in terms of good contrast and a variety of readouts. [1][2][3][4] However, organic substances have low photostability and are subject to luminescence quenching upon binding to biological molecules. 5,6 In addition, short luminescence lifetimes and wide bands of organic substances make it difficult to detect their luminescence in vivo due to cell autofluorescence.…”

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confidence: 99%