2017
DOI: 10.18632/aging.101188
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Abstract: We tested the feasibility of setting individualized glycemic goals and factors influencing targets set in a clinical trial in elderly patients with type 2 diabetes.A 24-week, randomized, double-blind, placebo-controlled study was conducted in 45 outpatient centers in seven European countries. 278 drug-naïve or inadequately controlled (mean HbA1c 7.9%) patients with type 2 diabetes aged ≥70 years with HbA1c levels ≥7.0% and ≤10.0% were enrolled. Investigator-defined individualized HbA1c targets and the impact o… Show more

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Cited by 19 publications
(15 citation statements)
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References 23 publications
(35 reference statements)
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“…To date, however, only one study has even attempted to demonstrate the feasibility of individualising care [ 23 ]. Whilst the INTERVAL study demonstrated that achieving individualised glycaemic targets was feasible, process of setting such targets themselves was very difficult [ 24 ].…”
Section: Discussionmentioning
confidence: 99%
“…To date, however, only one study has even attempted to demonstrate the feasibility of individualising care [ 23 ]. Whilst the INTERVAL study demonstrated that achieving individualised glycaemic targets was feasible, process of setting such targets themselves was very difficult [ 24 ].…”
Section: Discussionmentioning
confidence: 99%
“… 45 Surprisingly, men were set more aggressive targets than women (p=0.026; Figure 2 ), whereas setting targets according to the frailty status demonstrated only a trend towards significance (p=0.068). 46 In non-frail patients, the baseline weight predicted a less aggressive glycaemic target setting (p=0.012), while astonishingly, glycaemic targets were not adjusted according to the body weight in frail patients (p=0.725; Figure 3 ). 46 …”
Section: Managing Diabetes In Older Adultsmentioning
confidence: 99%
“…Later it was concluded that despite extensive training and guidance the physicians in the study did not differ from the traditional glycaemic settings and therefore did not personalise the treatment strategy. 56 The MID FRAIL study recently compared a modular intervention consisting of education, exercise and personalised metabolic targets against usual care in frail people with T2D of 70 years and older, and this was the first study to show positive functional outcomes after one year which were cost-effective. 57 In summary, it is generally accepted that metabolic control in older people should be relaxed in phase with increasing multimorbidity and frailty.…”
Section: Personalised Medicine In Older People With T2dmentioning
confidence: 99%