Individual variability in patterns and dynamics of fecal gluten immunogenic peptides excretion after low gluten intake

Coto, Laura; Sousa, Carolina; Cebolla, Ángel

doi:10.1007/s00394-021-02765-z

Cited by 14 publications

(18 citation statements)

References 42 publications

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“…GIP in stool samples (sGIP) were measured with an enzyme linked immunosorbent assay designed to detect GIP related to the 33-mer peptide using the iVYLISA GIP Stool kit (Biomedal Diagnostics; Madrid, Spain). GIPs were extracted from the samples as per manufacturer instructions, and the extract were added to multi-well plate coated with G12 monoclonal antibody which specifically recognizes the peptides (13). GIP in urine samples (uGIP) were measured using the iVY-CHECK GIP Urine kits (Biomedal Diagnostics; Madrid, Spain).…”

Section: Gip Testsmentioning

confidence: 99%

Gluten Immunogenic Peptides Are Not Correlated With Reported Adherence to Gluten-Free Diet in Children With Celiac Disease

Guz‐Mark

Perets

Biran

et al. 2023

Journal of Pediatric Gastroenterology &Amp; Nutrition

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Objective: There is no gold standard to assess adherence to gluten-free diet (GFD) among patients with celiac disease (CeD). Gluten immunogenic peptides (GIPs) in urine and stool were suggested as novel markers for evaluating adherence to GFD. Our aim was to assess the presence of GIP in pediatric patients with CeD, and to compare the results with alternative methods for evaluating GFD adherence. Methods: Pediatric patients diagnosed with CeD, who were on GFD for at least 1 year, were enrolled and followed prospectively between November 2018 and January 2021. Study visits included clinical assessment, a dietitian interview, Biagi score, food questionnaires, anthropometric and laboratory measurements, and urine and stool samples obtained for laboratory GIP analysis. Results: The study included 74 patients (63.5% females), with median (interquartile range, IQR) age of 9.9 (7.8–11.7) years, and median (IQR) duration on GFD of 2.5 (2–5.5) years. Good GFD adherence, assessed by Biagi score, was reported in 93.1% of cases. GIP was evaluated during 134 visits, with GIP detected in 27 of 134 (20.1%) of the visits (16.3% of stool samples and 5.3% of urine samples). Positive GIP results were significantly more common in males compared to females (30.6% vs 14.1%, respectively, P < 0.05). Detection of positive GIP was not associated with dietary assessment of GFD adherence, celiac serology results, or reported symptoms. Conclusions: Stool and urine GIP can be detected in children with CeD, even when dietary assessment indicate good adherence to GFD. The role of GIP testing in clinical practice should be further explored.

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Section: Gip Testsmentioning

confidence: 99%

Gluten Immunogenic Peptides Are Not Correlated With Reported Adherence to Gluten-Free Diet in Children With Celiac Disease

Guz‐Mark

Perets

Biran

et al. 2023

Journal of Pediatric Gastroenterology &Amp; Nutrition

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“…Stool Children Case-control study [87] Cohort study [96] Prospective study [89] Transversal study [97] Systematic revision [98] Prospective study [99] Observational descriptive study [100] Children and adults Prospective study [88] Transversal study [101,102] Adults Observational prospective study [103] Prospective study [104] Prospective study [105] Urine Children and adults Controlled study [106] Randomized controlled study [90] Adults Transversal study [107] Prospective study [108] Prospective study [109] Prospective study [110] Stool and urine Children and adults Meta-analysis [111] Adults Prospective study [80] Prospective study [1 7, 7 7 ] Prospective study [112] Table 2.…”

Section: Study Design Referencesmentioning

confidence: 99%

Celiac Disease, Management, and Follow-Up

Ruiz-Carnicer¹,

Segura²,

Sousa³

et al. 2022

Immunology of the GI Tract - Recent Advances

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Celiac disease (CD) is a systemic immune-mediated disorder characterized by a specific serological and histological profile triggered by gluten ingestion, which is given in genetically predisposed subjects. Heterogeneous clinical presentation is characteristic in CD, affecting any organ or tissue with gastrointestinal, extraintestinal, seronegative, or nonresponsive manifestations. CD diagnosis is based on several criteria, including genetic and serological tests, clinical symptoms and/or risk conditions, and duodenal biopsy. Currently, the available treatment for CD is a strict gluten-free diet (GFD) that essentially relies on the consumption of naturally gluten-free foods, such as animal-based products, fruits, vegetables, legumes, and nuts, as well as gluten-free dietary products that may not contain more than 20 mg of gluten per kg of food according to Codex Alimentarius. However, it is difficult to maintain a strict oral diet for life and at least one-third of patients with CD are exposed to gluten. Difficulties adhering to a GFD have led to new tools to monitor the correct adherence to GFD and alternative forms of treatment.

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“…A strict lifelong gluten-free diet (GFD) is the only treatment currently available for CD patients. However, adherence to the GFD is difficult due to the large number of gluten-containing products and cross-contamination [ 6 ]. Socioeconomic aspects also play an important role.…”

Section: Introductionmentioning

confidence: 99%

The Importance of an Early Evaluation after Establishing a Gluten-Free Diet in Children with Celiac Disease

et al. 2023

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A gluten-free diet (GFD) is the only treatment available for celiac disease (CD); hence, it is important to ensure correct adherence to the diet and adequate monitoring of the diet. The present study aims to assess the importance of an early follow-up of celiac patients after diagnosis of the disease, identify the role of stool gluten immunogenic peptides (GIPs) in the assessment of GFD adherence, and analyze possible nutritional imbalances or deficiencies in the GFD. This is a cross-sectional study carried out in pediatric patients with newly diagnosed CD in a tertiary hospital in Spain. Of the 61 patients included, 14% had positive stool GIPS at 4 months after CD diagnosis, Among them, 88% had negative stool GIPS at 9 months after diagnosis, following dietary advice. We found nutritional deficiencies in the GFD, such as vitamin D (with only 27% of patients with adequate intakes), folate, calcium, magnesium, and fiber. Similarly, we found imbalances: excess protein and fat intakes and a high percentage of total daily energy intake came from ultra-processed foods (UPF). These findings emphasize the importance of early follow-up of children after diagnosis of CD. It is also crucial to identify patients with poor GFD compliance based on stool GIPS and analyze GFD nutritional imbalances and deficits. Our findings may contribute to the development of specific strategies for the early follow-up of patients with CD, including appropriate nutritional counselling.

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Individual variability in patterns and dynamics of fecal gluten immunogenic peptides excretion after low gluten intake

Cited by 14 publications

References 42 publications

Gluten Immunogenic Peptides Are Not Correlated With Reported Adherence to Gluten-Free Diet in Children With Celiac Disease

Gluten Immunogenic Peptides Are Not Correlated With Reported Adherence to Gluten-Free Diet in Children With Celiac Disease

Celiac Disease, Management, and Follow-Up

The Importance of an Early Evaluation after Establishing a Gluten-Free Diet in Children with Celiac Disease

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