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Cited by 24 publications
(28 citation statements)
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References 34 publications
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“…Sönnichsen et al showed that slice culture from patient-derived colorectal tumor tissue represented similar morphological features to the original tumor over the observed cultivation period of 3 days. Persisting tumor cell proliferation in tissue slice culture under treatment with 5-FU, as highlighted in the study, can help identify a non-responding patients to a treatment, and therefore may help in preventing administration of ineffective treatment in clinically applicable timeframe [69]. Unlike 3D culture models, the initial step for this technique does not include an enzymatic digestion step of the tumor-tissue before the cells are stimulated to grow in 3D, which, in turn, makes it possible to maintain the complexity of the tumor without extra manipulation of the tissue [63].…”
Section: Patient-derived Tissue Slice Culturementioning
confidence: 93%
See 1 more Smart Citation
“…Sönnichsen et al showed that slice culture from patient-derived colorectal tumor tissue represented similar morphological features to the original tumor over the observed cultivation period of 3 days. Persisting tumor cell proliferation in tissue slice culture under treatment with 5-FU, as highlighted in the study, can help identify a non-responding patients to a treatment, and therefore may help in preventing administration of ineffective treatment in clinically applicable timeframe [69]. Unlike 3D culture models, the initial step for this technique does not include an enzymatic digestion step of the tumor-tissue before the cells are stimulated to grow in 3D, which, in turn, makes it possible to maintain the complexity of the tumor without extra manipulation of the tissue [63].…”
Section: Patient-derived Tissue Slice Culturementioning
confidence: 93%
“…The exact number of tumor cells in the tissue slice culture is not determined prior to the initiation step, which can greatly impact the reproducibility of the results [65]. While this model represents a promising technology to assess drug sensitivity in individual colorectal tumors, further correlations with clinical outcomes in larger cohorts of patients to validate the clinical application of the technique, are to be considered [69].…”
Section: Patient-derived Tissue Slice Culturementioning
confidence: 99%
“…Slice cultures of gastric cancer samples were prepared as previously described [30]. Briefly, after surgical resection and pathological assessment tumor specimens were cut into 350 μm slices by using a tissue chopper (McIlwain TC752; Campden Instruments, Leicestershire, England).…”
Section: Methodsmentioning
confidence: 99%
“…Also, artificial 2D or 3D matrices poorly mimic the in vivo situation, which consists, in addition to the ECM, of multiple cell types that are capable of influencing and interacting with tumor cells, and thus substantially affect their invasive potential [ 8 ]. Aiming at systems that provide an organotypic microenvironment with its required cellular complexity [ 9 , 10 ], more recent studies have developed tissue slice models in an air-liquid interface setting [ 11 , 12 , 13 , 14 ]. This also included tissue slice co-culture models.…”
Section: Introductionmentioning
confidence: 99%