Individual Morphological Variations Seen in Australia Antigen Positive Sera

Electron microscopic study of the distribution of the Australia antigen in individual sera of 50 serologically positive blood donors and two patients with serum hepatitis

“…The procedure therefore is a reasonably sensitive one and it is quite Antigen particles varied very considerably in relative proportion and in amount and the morphology was identical with that described by Bayer, Blumberg, and Werner (1968), Almeida, Zuckerman, Taylor, and Waterson (1969), Dane et al (1970), and Almeida (1972). If the Dane particles prove to be the infectious virus particles it is noteworthy that at least 30% of these donors had virus particles in their blood.…”

Effects of adenine arabinoside on serum and intrahepatic replicative forms of duck hepatitis B virus in chronic infection

“…These possibilities have not been studied, but neither are likely to explain the much larger dose of Ara-A required to see an effect in ducks. It has been estimated that most chronic carriers of HBV have approximately lo6 Dane particles per ml of serum (24); in contrast, young, chronically infected ducks have approximately 10'' DHBV genome equivalents per ml of serum (unpublished data). This suggests that our young, experimentally infected ducks may have a much larger virus load than adult human HBV carriers.…”

Correlations between the detection of e antigen or antibody and electron microscopic pattern of hepatitis B surface antigen (HBsAg) associated particles in the serum of HBsAg carriers.

“…Striking differences in the infectivity of these various types of carriers has been observed (Magnius and Espmark, 1972;Heathcote et al, 1974) and the remarkable abundance of Dane particles in haemodialysis and chronic hepatitis is well documented (Almeida, 1972;Couleru et al, 1973;Yamada, 1974). However, the frequency of detection of Dane particles in CAC remains controversial.…”