2015
DOI: 10.1515/bvip-2015-0057 View full text |Buy / Rent full text
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Abstract: The aim of this study was to determine the correlation between lipophilicity and maximum residue limit (MRL) value specified for veterinary drugs in the fatty tissue of various animal species. The analysis was performed on a group of 73 compounds with different modes of action and MRL values determined for the fatty tissue of animals. Additionally, the logarithm of water/organic phase partition ratio (LogP) and the ratio of ionised and unionised substance in buffer with pH 7.4 (LogD7.4) were calculated. The ma… Show more

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“…RAF is a poorly watersoluble drug with a LogD of 6.76 in a pH 7.4 buffer. 14 Its solubility is less than 0.1 μg/mL in purified water, and this increases to 10.7 μg/mL in a 0.1 N sodium hydroxide (NaOH) solution. The low solubility of RAF in aqueous media is mainly attributed to its high LogD.…”
Section: Resultsmentioning
“…RAF is a weak acid with a p K a of 4.6. RAF is a poorly water-soluble drug with a LogD of 6.76 in a pH 7.4 buffer . Its solubility is less than 0.1 μg/mL in purified water, and this increases to 10.7 μg/mL in a 0.1 N sodium hydroxide (NaOH) solution.…”
Section: Resultsmentioning
“…The degree of tylosin binding to milk protein was reported to be 15% in another study (Ziv and Sulman, 1973). Although lipophilic drugs bind to plasma and tissue proteins at a high degree (Marczak et al, 2015), the binding ratios of drugs to milk and plasma proteins may be different (Atkinson and Begg, 1990). Also, the binding affinities of drugs to Figure 1.…”
Section: Discussionmentioning
“…One potential method to increase the CSF concentration of ponazuril is suggested by the observation that ponazuril is a highly lipophilic compound 4 . If coadministration of ponazuril with oil enhances absorption of ponazuril this would be an economical means to enhance absorption and thereby increase serum and CSF concentrations, possibly improving effectiveness of treatment.…”
Section: Introductionmentioning