Indeterminate Orbital Masses: Restricted Diffusion at MR Imaging with Echo-planar Diffusion-weighted Imaging Predicts Malignancy

Sepahdari, Ali R.; Aakalu, Vinay K.; Setabutr, Pete; Shiehmorteza, Masoud; Naheedy, John; Mafee, Mahmood F.

doi:10.1148/radiol.10091956

Cited by 123 publications

(162 citation statements)

References 21 publications

(8 reference statements)

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“…Contrary to the findings described by Abdel Razek et al, 4 Sepahdari et al 8 reported that retinoblastomas had an ADC of 0.93 6 0.3 3 10 23 mm 2 s 21 , which is in line with our results. They also mentioned that the ADCs of the retinoblastomas were strongly inversely correlated with the lesion thickness, likely representing the effect of partial volume averaging.…”

Section: Discussionsupporting

confidence: 90%

“…[7][8][9][10][11] Previous reports showed variable DWI intensities and ADCs in retinoblastomas, depending on their histology and cellularity. 3 Abdel Razek et al 4 reported that the mean ADC was 0.49 6 0.12 3 10 23 mm 2 s 21 on EP imaging, which is lower than the mean ADC of the present study.…”

Section: Discussionmentioning

confidence: 98%

“…They also mentioned that the ADCs of the retinoblastomas were strongly inversely correlated with the lesion thickness, likely representing the effect of partial volume averaging. 8 The high spatial resolution of DSDE-TFE might solve this problem.…”

Section: Discussionmentioning

confidence: 99%

“…2,5 Diffusion-weighted imaging (DWI) is widely used to diagnose tumours, inflammation and vascular disease in both intracranial and extracranial lesions. 3,4,[6][7][8][9][10][11][12][13][14][15][16] Previous studies also revealed the efficacy of DWI to evaluate orbital lesions including orbital tumours of adults 8,9 and children, 10 ocular adnexal lymphomas, 9,11 immunoglobulin G4 (IgG4)-related disease, 9 endophthalmitis 12 and optic nerve lesions. 13,14 However, it is sometimes difficult to evaluate intraorbital structures with echoplanar (EP) imaging, which is the most common imaging technique for DWI.…”

Section: Introductionmentioning

confidence: 99%

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3D turbo field echo with diffusion-sensitized driven-equilibrium preparation technique (DSDE-TFE) versus echo planar imaging in evaluation of diffusivity of retinoblastoma

Hiwatashi¹,

Togao²,

Yamashita³

et al. 2016

BJR

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Makoto Obara is an employee of Philips Electronics Japan. He was not involved in data analysis in this study.Objective: Compared with echoplanar (EP) diffusionweighted imaging (DWI), three-dimensional (3D) turbo field echo with diffusion-sensitized driven-equilibrium (DSDE-TFE) preparation DWI obtains images with higher spatial resolution and less susceptibility artefacts. The purpose of this study was to evaluate the feasibility of DSDE-TFE to visualize retinoblastomas compared with EP imaging. Methods: This retrospective study was approved by our institutional review boards. Eight patients with retinoblastomas (five males and three females; age range 0-87 months; median 21 months) were studied. For the DSDE-TFE, motion-probing gradients (MPGs) were conducted at one direction with b-values of 0 and 500 s mm 22 and a voxel size of 1.5 3 1.5 3 1.5 mm 3 . For the EP imaging, MPGs were conducted at three directions with b-values of 0 and 1000 s mm 22 and a voxel size of 1.4 3 1.8 3 3 mm 3 . The apparent diffusion coefficients (ADCs) of each lesion were measured. Statistical analyses were performed with Pearson R and linear correlation coefficients. Results: Intraocular lesions were clearly visualized on the DSDE-TFE without obvious geometrical distortion, whereas all showed deformity on EP images. On the DSDE-TFE, the ADCs of the lesions ranged from 0.83 3 10 23 to 2.93 3 10 23 mm 2 s 21 (mean 6 standard deviation 1.73 6 0.73 3 10 23 mm 2 s 21 ). On the EP images, the ADCs ranged from 0.53 3 10 23 to 2.03 3 10 23 mm 2 s 21 (0.93 6 0.53 3 10 23 mm 2 s 21 ). There was a significant correlation in ADC measurement between the DSDE-TFE and EP imaging (r 5 0.81, p , 0.05). Conclusion: With its insensitivity to field inhomogeneity and high spatial resolution, the 3D DSDE-TFE technique enabled us to assess diffusivity in retinoblastomas. Advances in knowledge: DSDE-TFE could enable us to assess the ADC of retinoblastomas without obvious geometrical distortion.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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3D turbo field echo with diffusion-sensitized driven-equilibrium preparation technique (DSDE-TFE) versus echo planar imaging in evaluation of diffusivity of retinoblastoma

Hiwatashi¹,

Togao²,

Yamashita³

et al. 2016

BJR

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“…Several case series and case reports have used DWI to characterize orbital masses, inflammatory lesions, and infection; and additional scattered case reports are available describing the use of DWI to characterize ocular lesions such as endophthalmitis. [6][7][8][9][10] Isolated examples of DWI of retinoblastoma have also been reported (Castillo M, "More on DWI of Head and Neck Lesions" January 1, 2009; ajnrblog.org). 11 To our knowledge, there has not yet been a systematic analysis of ocular masses by using DWI.…”

mentioning

confidence: 99%

Diffusion-Weighted Imaging of Malignant Ocular Masses: Initial Results and Directions for Further Study

Sepahdari¹,

Kapur²,

Aakalu³

et al. 2011

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE: Ocular masses represent a spectrum of malignant tumors and benign lesions that are sometimes difficult to detect and differentiate by conventional imaging techniques. The aim of this study was to characterize a group of malignant ocular masses with DWI, with the goals of establishing reference data and identifying potential clinical applications for improved noninvasive characterization.

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Role of magnetic resonance diffusion-weighted imaging in differentiating lacrimal masses

Zhang

Sha

Jiao

et al. 2013

J. Magn. Reson. Imaging

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Indeterminate Orbital Masses: Restricted Diffusion at MR Imaging with Echo-planar Diffusion-weighted Imaging Predicts Malignancy

Abstract: Echo-planar DW MR imaging can help characterize indeterminate orbital masses.

Cited by 123 publications

References 21 publications

3D turbo field echo with diffusion-sensitized driven-equilibrium preparation technique (DSDE-TFE) versus echo planar imaging in evaluation of diffusivity of retinoblastoma

3D turbo field echo with diffusion-sensitized driven-equilibrium preparation technique (DSDE-TFE) versus echo planar imaging in evaluation of diffusivity of retinoblastoma

Diffusion-Weighted Imaging of Malignant Ocular Masses: Initial Results and Directions for Further Study

Role of magnetic resonance diffusion-weighted imaging in differentiating lacrimal masses

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