Incremental value of three-dimensional echocardiography for evaluating left atrial function in patients with coronary slow flow phenomenon: a case control study

Li, Jun; Wang, Yonghuai; Zhao, Cuiting; Zhu, Qing; Li, Guangyuan; Jun, Yang; Jia, Dalin; Ma, Chao

doi:10.1186/s12947-020-00189-z

Cited by 6 publications

(4 citation statements)

References 25 publications

(25 reference statements)

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“…Altered LA volume and function are also associated with CSFP. Li jun et al [38] noted that decreased LA systolic function in patients with CSFP was related to decreased coronary flow velocities and the number of involved arteries. Another small study noted that CSFP was linked to increased LA volume, impaired LA reserve function, and enhanced systolic function [39].…”

Section: Discussionmentioning

confidence: 99%

Asymmetric Dimethylarginine Is Associated with the Phenomenon of Coronary Slow Flow in Patients with Nonvalvular Atrial Fibrillation

Du,

Jiang,

et al. 2024

Cardiology

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Objective: Coronary slow flow phenomena (CSFP) is associated with endothelial and blood component abnormalities in coronary arteries. Asymmetric dimethylarginine (ADMA) can damage the endothelium of the heart or blood vessels in patients with non-valvular atrial fibrillation (NVAF), causing changes in biological medium content. The factors related to the occurrence of CSFP in NVAF patients are currently unknown. Our aim is to analyze the relationship between ADMA and CSFP in NVAF patients. Methods: We consecutively enrolled 134 patients diagnosed with NVAF and underwent coronary angiography, 50 control patients without a history of atrial fibrillation and with normal coronary angiographic flow were included at the same time. Based on the corrected TIMI frame count (CTFC), the NVAF patients were categorized into two groups, CTFC≤27 frames and CTFC>27 frames. Plasma ADMA, p-seletion (p-sel), von Willebrand Factor (vWF), D-dimer (D-Di), fibrinogen activator inhibitor-1 (PAI-1) and nitric oxide (NO) were detected by ELISA in the different groups. We counted the general clinical data and analyzed the factors associated with the presence of CSFP on coronary angiography in NVAF patients. Results: We found that plasma ADMA levels were significantly higher among NVAF patients in the CTFC >27 grade group compared with the control or CTFC ≤27 group. In addition, the levels of blood cells and endothelium-related biomarkers (NO, p-seletion, vWF, D-Di, and PAI-1) were significantly altered and correlated with ADMA levels. Multifactorial analysis showed that plasma ADMA [OR (95%CI): 1.65 (1.21-2.43), p<0.001] and left atrial internal diameter [OR (95%CI): 1.04 (1.02, 1.1), p<0.001] could be used as independent risk factors for the development of CSFP in patients with NVAF. The ROC curves of ADMA can predict the development of CSFP in NVAF patients. The minimum diagnostic concentration for the development of CSFP in patients was 2.31 µmol/L. Conclusion: Our study suggests that the high levels of ADMA and left atrial internal diameter in vivo in patients with NVAF can contribute to the development of CSFP. Therefore, aggressive preoperative detection and evaluation of ADMA and left atrial internal diameter can help to deal with the intraoperative presence of CSFP.

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Section: Discussionmentioning

confidence: 99%

Asymmetric Dimethylarginine Is Associated with the Phenomenon of Coronary Slow Flow in Patients with Nonvalvular Atrial Fibrillation

Du,

Jiang,

et al. 2024

Cardiology

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“…This study found that the author with the most publications was Chun-Yan Ma from China. The studies of her team have mainly concentrated on the novel echocardiography-based technique to assess CSF and gene polymorphisms in the pathogenesis of CSF [ 8 , 9 ]. Six of the top 15 authors by publications on CSF were from Turkey, and some authors had very close co-operative relationships.…”

Section: Discussionmentioning

confidence: 99%

Coronary slow flow research: a bibliometric analysis

Tong,

Bei,

Zhang

et al. 2023

Eur J Med Res

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Background Studies on coronary slow flow are receiving increasing attention, but objective evaluations are still lacking. The purpose of this study was to visualize the current status and research hotspots of coronary slow flow through bibliometric analysis. Methods All relevant publications on coronary slow flow from 2003 to 2022 were extracted from the Web of Science Core Collection database and analyzed by VOSviewer and CiteSpace visualization software. Year of publication, journal, country/region, institution, and first author of each paper, as well as research hotspots were identified. Results A total of 913 publications were retrieved. The journal with the most publications was Coronary Artery Disease. The country/region with the most publications was Turkey, followed by China and the United States. The institution with the largest publication volume was Turkey Specialized Higher Education Research Hospital. The author with the largest publication volume was Chun-Yan Ma from China. Keyword analysis indicated that “treatment and prognosis”, “pathogenesis and risk factors” and “diagnosis” were the clustering centers of coronary slow flow, and the research hotspots gradually changed with time, from pathogenesis to treatment and prognosis. Conclusion Future research will focus on the search for effective and non-invasive detection indicators and treatments of coronary slow flow. Collaboration needs to be enhanced between different institutions or countries/regions, which would improve clinical outcomes for patients with coronary slow flow.

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“…However, the effect of CSFP on left atrial function has been minimally investigated. A few studies can be found in the existing literature, but the conclusion is controversial [38,39]. Left atrium plays an important role in ensuring proper performance of left ventricular function and the systemic circulation.…”

Section: Csfp and Left Atrial Functionmentioning

confidence: 99%