Incremental prognostic value of MRI in the staging of early cervical cancer: a prospective study and review of the literature

Bourgioti, Charis; Chatoupis, Konstantinos; Rodolakis, Alexandros; Antoniou, Aris; Tzavara, Chara; Koutoulidis, Vassilis; Moulopoulos, Lia A.

doi:10.1016/j.clinimag.2015.09.012

Cited by 36 publications

(24 citation statements)

References 20 publications

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“…When there is total loss of the hypointense cervical rim without parametrial irregularity, it may be hard to identify early extension of the tumor to parametrial tissue; this leads to lower accuracy rates for detection of parametrial invasion in this subset of patients [30,35] . False positive results may occur when peritumoral post-biopsy or inflammatory changes are present.…”

Section: Mri: Indications Findings and Limitationsmentioning

confidence: 99%

“…Reported MRI accuracy values for parametrial extension range from 88%-97%, significantly higher compared to clinical examination. When information acquired from MRI is added to clinical assessment, the predictive ability of the latter significantly increases [5,26,30,31] .…”

Section: Mri: Indications Findings and Limitationsmentioning

confidence: 99%

“…FIGO guidelines for the staging of cervical cancer include a significant number of timeconsuming "old fa [5,21,26,[28][29][30] . Clinical staging of early cervical cancer and assessment of important prognostic factors significantly improves when MRI information is added to the clinical data; MRI helps select surgical candidates among patients with cervical cancer, because it has a high negative predictive value (94%-100%) for parametrial involvement.…”

Section: Imaging Modalities For Cervical Cancer Stagingmentioning

confidence: 99%

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Current imaging strategies for the evaluation of uterine cervical cancer

Bourgioti

Chatoupis

Moulopoulos

2016

WJR

Self Cite

104

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Uterine cervical cancer still remains an important socioeconomic issue because it largely affects women of reproductive age. Prognosis is highly depended on extent of the disease at diagnosis and, therefore, accurate staging is crucial for optimal management. Cervical cancer is clinically staged, according to International Federation of Gynecology and Obstetrics guidelines, but, currently, there is increased use of cross sectional imaging modalities [computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography-CT (PET-CT)] for the study of important prognostic factors like tumor size, parametrial invasion, endocervical extension, pelvic side wall or adjacent/distal organs involvement and lymph node status. Imaging indications also include cervical cancer follow-up, evaluation of tumor response to treatment and selection of suitable candidates for less radical surgeries like radical trachelectomy for fertility preservation. The preferred imaging method for local cervical cancer evaluation is MRI; CT is equally effective for evaluation of extrauterine spread of the disease. PET-CT shows high diagnostic performance for the detection of tumor relapse and metastatic lymph nodes. The aim of this review is to familiarize radiologists with the MRI appearance of cervical carcinoma and to discuss the indications of cross sectional imaging during the course of the disease in patients with cervical carcinoma.

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Section: Mri: Indications Findings and Limitationsmentioning

confidence: 99%

Section: Mri: Indications Findings and Limitationsmentioning

confidence: 99%

Section: Imaging Modalities For Cervical Cancer Stagingmentioning

confidence: 99%

See 1 more Smart Citation

Current imaging strategies for the evaluation of uterine cervical cancer

Bourgioti

Chatoupis

Moulopoulos

2016

WJR

Self Cite

104

View full text Add to dashboard Cite

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“…42,43 The anesthetic intervention also includes risks, independent of surgical intervention, that must be taken in consideration, and the technique has to ensure the safety of both the mother and the embryo. This is achieved by understanding the physiological and pharmacological changes that occur during pregnancy by avoiding potentially dangerous drugs in critical phases of intrauterine development, ensuring continuous adequate uteroplacental circulation and to prevent or treat a premature birth.…”

Section: Discussionmentioning

confidence: 99%

Abdominal Radical Trachelectomy for Early-Stage Cervical Cancer During Pregnancy: A Provocative Surgical Approach. Overview of the Literature and a Single-Institute Experience

Rodolakis

Thomakos

Sotiropoulou³

et al. 2018

Int J Gynecol Cancer

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ObjectiveTreatment of pregnancy complication due to malignancy of the cervix constitutes a great clinical challenge between optimal maternal therapy and fetal viability. Radical trachelectomy in early-stage cervical cancer during pregnancy instead of radical hysterectomy presents an alternative approach that can offer a satisfactory outcome for the mother and fetus.Materials and Methods–ResultsA literature search of articles in English has been performed. Until now, 28 women with cervical cancer, including 2 who were managed and treated in our institute, who underwent a radical trachelectomy during pregnancy have been reported. We overviewed a total of 13 abdominal trachelectomies, 13 vaginal trachelectomies, and 2 laparoscopic trachelectomies.ConclusionsRadical trachelectomy can widen the therapeutic approach of early-stage cervical cancer in pregnant women who wish to preserve their pregnancy, providing a possibility of receiving the proper treatment with no delay.

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“…The introduction of imaging in treatment planning enables more meticulous and individualized treatment planning . It facilitates a reduction in the number of women treated both with surgical treatment and chemo‐radiation and in addition induces a safer adaption of the treatment to the patient's preference, often dependent on the age and desire for future fertility.…”

Section: Discussionmentioning

confidence: 99%