Increasingly complex DNA assemblies

DNA-Driven Dynamic Assembly/Disassembly of Inorganic Nanocrystals for Biomedical Imaging

“…The toehold enables the displacement of the original strand by the binding strand, resulting in a change in DNA configuration and dynamic assembly/disassembly of DNA-NC conjugates. For example, Gang and coauthors reprogrammed the DNA-mediated interactions with the NCs, selectively manipulating the transformations between NC superlattices, which showed that DNA-exchange reactions enable dynamic reconfiguration and switchable structures in NC assembly, providing multiple-stage activation and diverse functional capabilities. ,, …”

“…For example, Gang and coauthors reprogrammed the DNA-mediated interactions with the NCs, selectively manipulating the transformations between NC superlattices, which showed that DNA-exchange reactions enable dynamic reconfiguration and switchable structures in NC assembly, 69 providing multiple-stage activation and diverse functional capabilities. 69,110,111 In the past decades, several new tools based on SDR have been developed for enhancing disease-related nucleic acid sensing, which demonstrates that DNA is capable of customizing dynamic NC assembly with controllable optical 112 and magnetic 113 properties, and expanding the applications of NCs in biomedical imaging. 114,115 For instance, Ma et al created a quantum dots (QD) computing system based on fluorescence resonance energy transfer (FRET) through the dynamic assembly of polychromatic QD with DNA, which can image disease-related nucleic acid molecules (e.g., microRNA and mRNA).…”

“…For example, Gang and coauthors reprogrammed the DNA-mediated interactions with the NCs, selectively manipulating the transformations between NC superlattices, which showed that DNA-exchange reactions enable dynamic reconfiguration and switchable structures in NC assembly, 69 providing multiple-stage activation and diverse functional capabilities. 69 , 110 , 111 …”