Increasing nitric oxide production improves survival in experimental hemorrhagic shock

L-Arginine infusion during resuscitation for hemorrhagic shock

“…Studies show that increasing NO availability can improve perfusion and attenuate inflammation in a wide variety of clinical scenarios. 9–11,23 Our previous studies have shown that pretreatment with L-Arg improves survival in a swine model of severe trauma and hemorrhagic shock and resuscitation injury (unpublished data).…”

L-Arginine infusion during resuscitation for hemorrhagic shock

“…Studies show that increasing NO availability can improve perfusion and attenuate inflammation in a wide variety of clinical scenarios. 9–11,23 Our previous studies have shown that pretreatment with L-Arg improves survival in a swine model of severe trauma and hemorrhagic shock and resuscitation injury (unpublished data).…”

Hypertonic Resuscitation Improves Neuronal and Behavioral Outcomes after Traumatic Brain Injury plus Hemorrhage

“…17 Furthermore, Larginine produced favorable effects on the heart rate and tissue oxygenation in hemorrhaged rabbits 31 and increased survival in hemorrhaged rats. 12 In the same TBI/ hemorrhage model that was used in the current study, both hypertonic saline and hypertonic L-arginine improved MAP and CBF equally, but long-term outcome was not examined. 18 Therefore, the current study was designed to determine whether acute improvements in MAP, ICP, and CBF in response to hypertonic resuscitation were associated with increased neuronal survival and improved behavioral outcomes 15 days after TBI and hemorrhage.…”

“…9 L-Arginine, a precursor to the potent vasodilator nitric oxide, increases blood flow to vital organs, 10 possibly through vasodilator actions that contribute to maintaining nutritional flow to tissue during acute hemorrhage. 11 In hemorrhaged rats, L-arginine improved survival rate 12 and macrophage function. 13 Under normal physiologic conditions, L-arginine concentrations in endothelial cells are sufficient for basal production of nitric oxide (i.e., L-arginine availability is not rate limiting); however, under conditions of excessive ischemia-induced formation of nitric oxide, local L-arginine concentrations may be inadequate.…”

Trauma Induces Intravascular Hemolysis, Exacerbated by Red Blood Cell Transfusion and Associated With Disrupted Arginine–nitric Oxide Metabolism

“…It would seem that arginine administration has therapeutic utility in trauma, and indeed, the benefits of L-arginine administration on NO production and outcome have been demonstrated in multiple animal models of trauma and hemorrhagic shock (16)(17)(18)(19). In one study, D-arginine in the resuscitation fluid did not improve organ blood flow following trauma-hemorrhage, whereas L-arginine did (19).…”

L-Arginine infusion during resuscitation for hemorrhagic shock

“…Studies show that increasing NO availability can improve perfusion and attenuate inflammation in a wide variety of clinical scenarios. 9–11,23 Our previous studies have shown that pretreatment with L-Arg improves survival in a swine model of severe trauma and hemorrhagic shock and resuscitation injury (unpublished data).…”

Hypertonic Resuscitation Improves Neuronal and Behavioral Outcomes after Traumatic Brain Injury plus Hemorrhage

“…17 Furthermore, Larginine produced favorable effects on the heart rate and tissue oxygenation in hemorrhaged rabbits 31 and increased survival in hemorrhaged rats. 12 In the same TBI/ hemorrhage model that was used in the current study, both hypertonic saline and hypertonic L-arginine improved MAP and CBF equally, but long-term outcome was not examined. 18 Therefore, the current study was designed to determine whether acute improvements in MAP, ICP, and CBF in response to hypertonic resuscitation were associated with increased neuronal survival and improved behavioral outcomes 15 days after TBI and hemorrhage.…”

“…9 L-Arginine, a precursor to the potent vasodilator nitric oxide, increases blood flow to vital organs, 10 possibly through vasodilator actions that contribute to maintaining nutritional flow to tissue during acute hemorrhage. 11 In hemorrhaged rats, L-arginine improved survival rate 12 and macrophage function. 13 Under normal physiologic conditions, L-arginine concentrations in endothelial cells are sufficient for basal production of nitric oxide (i.e., L-arginine availability is not rate limiting); however, under conditions of excessive ischemia-induced formation of nitric oxide, local L-arginine concentrations may be inadequate.…”

Trauma Induces Intravascular Hemolysis, Exacerbated by Red Blood Cell Transfusion and Associated With Disrupted Arginine–nitric Oxide Metabolism

“…It would seem that arginine administration has therapeutic utility in trauma, and indeed, the benefits of L-arginine administration on NO production and outcome have been demonstrated in multiple animal models of trauma and hemorrhagic shock (16)(17)(18)(19). In one study, D-arginine in the resuscitation fluid did not improve organ blood flow following trauma-hemorrhage, whereas L-arginine did (19).…”

L-Arginine infusion during resuscitation for hemorrhagic shock

“…Studies show that increasing NO availability can improve perfusion and attenuate inflammation in a wide variety of clinical scenarios. 9–11,23 Our previous studies have shown that pretreatment with L-Arg improves survival in a swine model of severe trauma and hemorrhagic shock and resuscitation injury (unpublished data).…”

Hypertonic Resuscitation Improves Neuronal and Behavioral Outcomes after Traumatic Brain Injury plus Hemorrhage

“…17 Furthermore, Larginine produced favorable effects on the heart rate and tissue oxygenation in hemorrhaged rabbits 31 and increased survival in hemorrhaged rats. 12 In the same TBI/ hemorrhage model that was used in the current study, both hypertonic saline and hypertonic L-arginine improved MAP and CBF equally, but long-term outcome was not examined. 18 Therefore, the current study was designed to determine whether acute improvements in MAP, ICP, and CBF in response to hypertonic resuscitation were associated with increased neuronal survival and improved behavioral outcomes 15 days after TBI and hemorrhage.…”

“…9 L-Arginine, a precursor to the potent vasodilator nitric oxide, increases blood flow to vital organs, 10 possibly through vasodilator actions that contribute to maintaining nutritional flow to tissue during acute hemorrhage. 11 In hemorrhaged rats, L-arginine improved survival rate 12 and macrophage function. 13 Under normal physiologic conditions, L-arginine concentrations in endothelial cells are sufficient for basal production of nitric oxide (i.e., L-arginine availability is not rate limiting); however, under conditions of excessive ischemia-induced formation of nitric oxide, local L-arginine concentrations may be inadequate.…”

Trauma Induces Intravascular Hemolysis, Exacerbated by Red Blood Cell Transfusion and Associated With Disrupted Arginine–nitric Oxide Metabolism

“…It would seem that arginine administration has therapeutic utility in trauma, and indeed, the benefits of L-arginine administration on NO production and outcome have been demonstrated in multiple animal models of trauma and hemorrhagic shock (16)(17)(18)(19). In one study, D-arginine in the resuscitation fluid did not improve organ blood flow following trauma-hemorrhage, whereas L-arginine did (19).…”