Increasing incidence and mortality related to liver cancer in Australia: time to turn the tide

Cocker, Fiona; Yee, KC; Palmer, Andrew J.; Graaff, Barbara de

doi:10.1111/1753-6405.12889

Cited by 33 publications

(40 citation statements)

References 32 publications

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“…Among both males and females in Cyprus (43), France (44), and the Netherlands (45), incidence increased over one to two decades until the 2000s but was stable in Spain (46). One study in Australia reported increasing long-term trends among persons (and by sex) until 2014 (47).…”

Section: Liver Cancers Combinedmentioning

confidence: 99%

“…Many of the included studies highlighted the importance of continuing efforts to reduce the risks associated with viral hepatitis through primary (HBV vaccination) (23,25,27,48,49,60) and secondary prevention efforts. The latter include screening of high-risk populations (23,31,47,49,(51)(52)(53)61) and ensuring equitable access to curative therapies for HBV/HCV infections among all population subgroups (23,32,37,47,48,52,53,59). However, even if incidence of HCV-related HCC decreases in the future due to improved treatments and better control (75,81), this may be offset by the emerging etiological importance of NAFLD as a key risk factor (77,82).…”

Section: Proposed Drivers Of Incidence Trendsmentioning

confidence: 99%

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Global Trends in Incidence Rates of Primary Adult Liver Cancers: A Systematic Review and Meta-Analysis

et al. 2020

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Background: Primary liver cancer is a leading cause of cancer deaths worldwide. Global burden varies, reflecting geographical distribution of viral hepatitis. Our objective was to perform a systematic review and meta-analysis of published current trends in incidence of adult liver cancers and histological types worldwide. Methods: This study used systematic searches of PubMed, Embase, CINAHL, and Web of Science databases for English-language peer-reviewed articles published from 1 January 2008 to 01 September 2019. Inclusion criteria were population-based studies of adult liver cancer patients with quantitative estimates of temporal trends in incidence for liver cancers and/or histological types. For multiple studies from the same geographical area, only the publication that reported the most recent trends for the same cancer type and population subgroup was included. Review was conducted per PRISMA guidelines. Two authors independently extracted data and critically assessed studies. Proposed contributors to observed trends were extracted from included articles. Study-specific estimates of the annual percentage change (APC) in incidence rates with 95% confidence intervals (CIs) were pooled using random-effects meta-analysis models. Heterogeneity was measured using the I 2 statistics and publication bias evaluated using funnel plots and Egger's tests. Results: Overall, 53 studies met the inclusion criteria, of which 31 were included in the meta-analysis. Overall, pooled APC estimates were +0.8 (95% CI −0.3, +2.0) for liver cancers combined, +2.6 (95% CI +1.2, +4.0) for hepatocellular carcinoma (HCC), and +4.3 (95% CI +2.5, +6.1) for intrahepatic cholangiocarcinoma. Subgroup analyses indicated increasing trends for liver cancers (APC +3.2, 95% CI +2.5, +3.9) and HCC (APC +3.6, 95% CI +2.9, +4.4) in the region of North America/Europe/Australia, whereas corresponding trends were decreasing (APC −1.7, 95% CI −2.2, −1.1) and stable (APC −0.7, 95% CI −1.9, +0.5) in Asia, respectively. Dasgupta et al. Liver Cancer Incidence Trends Meta-Analysis Conclusions: Incidence is increasing for adult liver cancers and HCC in Western countries, whereas trends are decreasing in the Asian region, although still remaining high. Our findings highlight the importance of viral hepatitis control and lifestyle interventions to reduce global liver cancer burden. Ongoing surveillance is also vital to detect early shifts in incidence trends.

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Section: Liver Cancers Combinedmentioning

confidence: 99%

Section: Proposed Drivers Of Incidence Trendsmentioning

confidence: 99%

Global Trends in Incidence Rates of Primary Adult Liver Cancers: A Systematic Review and Meta-Analysis

et al. 2020

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“…The study by McWilliams et al 33 was excluded from the present review as it is an international study based on data from the Pancreatic Cancer Case-Control Consortium and so was the study by Ansari-Moghaddam et al 28 as it contains data collated from countries in the Asia-Pacific region. Thus, 22 studies [19][20][21][22][23][24][25][26][27][29][30][31][32][34][35][36][37][38][39][40][41][42] were included in the review. Table 1 lists the various studies included in the review highlighting the source of their information.…”

Section: Resultsmentioning

confidence: 99%

“…Table 1 lists the various studies included in the review highlighting the source of their information. [19][20][21][22][23][24][25][26][27][29][30][31][32][34][35][36][37][38][39][40][41][42] Incidence, mortality and survival in pancreatic cancer There has been a moderate increase in the average annual percentage change in pancreatic cancer incidence (0.496%, 95% confidence interval (CI) 0.187-0.807) from 1982 to 2014 and annual percentage change in the mortality (0.298, 95% CI 0.084-0.511) from the disease from 1998 to 2015. 20 Pancreatic cancer (5-year) survival ranks among the lowest of all cancers in Australia with a survival of 5.2% irrespective of the sex of the patient, 32 although this was an improvement from 3% recorded between 1982 and1987.…”

Section: Resultsmentioning

confidence: 99%

Pancreatic cancer in the Australian population: identifying opportunities for intervention

Barreto

D’Onise²

2020

ANZ Journal of Surgery

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Pancreatic cancer is a disease associated with a poor overall survival. Advances in surgical techniques have helped improve outcomes of patients who are amenable to surgical resection. Sadly, surgery is amenable in only a small percentage of patients with the disease. Thus, there is a need to direct efforts at reducing the overall risk of pancreatic cancer or facilitating its early detection. The current review focused on collating all the literature published to date on pancreatic cancer in Australia with an aim to identify opportunities for intervention (at a state or national level) that are specific to Australia so as to help improve the outcome of patients with pancreatic cancer.

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“…The incidence and mortality of hepatocellular carcinoma (HCC) continues to rise in Australia 34,35 , with a doubling in age-standardised mortality rates in the past 15 years. Most international liver societies recommend 6-monthly ultrasound-based surveillance of at-risk populations 36 , however, the data supporting its impact remain weak.…”

Section: Opportunities For Lynch Syndrome Testingmentioning

confidence: 99%

Cancer screening in Australia: future directions in melanoma, Lynch syndrome, and liver, lung and prostate cancers

Weber

Marshall

Rankin³

et al. 2019

Public Health Res Pract

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While Australia now has well-established national screening programs for breast, bowel and cervical cancers, research continues into the feasibility of developing systematic screening programs for a number of other cancers. In this paper, experts in their fields provide perspectives on the current state of play and future directions for screening and surveillance for melanoma, Lynch syndrome, and liver, lung and prostate cancers in Australia. Although the evidence does not support population screening, there may be opportunities to prevent thousands of deaths through systematic approaches to the early detection of lung cancer and melanoma, testing for Lynch syndrome, and organised surveillance for hepatocellular carcinoma among individuals at high risk-guided by targeted research. The paper also looks at what impact new prostate specific antigen testing guidelines are having on screening for prostate cancer.

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Increasing incidence and mortality related to liver cancer in Australia: time to turn the tide

Cited by 33 publications

References 32 publications

Global Trends in Incidence Rates of Primary Adult Liver Cancers: A Systematic Review and Meta-Analysis

Global Trends in Incidence Rates of Primary Adult Liver Cancers: A Systematic Review and Meta-Analysis

Pancreatic cancer in the Australian population: identifying opportunities for intervention

Cancer screening in Australia: future directions in melanoma, Lynch syndrome, and liver, lung and prostate cancers

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