J. Neurosci. Res. volume 86, issue 3, P525-530 2008 DOI: 10.1002/jnr.21520 View full text
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Jane Yip, Jean-Jacques Soghomonian, Gene J. Blatt

Abstract: It has been widely reported that in autism, the number of Purkinje cells (PCs) is decreased, and recently, decreased expression of glutamic acid decarboxylase 67 (GAD67) mRNA in Purkinje cells also has been observed. However, the autism literature has not addressed key GABAergic inputs into Purkinje cells. Inhibitory basket and stellate cell interneurons in the molecular layer of the cerebellar cortex provide direct key GABAergic input into Purkinje cells and could potently influence the output of Purkinje cel…

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