Increased vascular inflammation on PET/CT in psoriasis and the effects of biologic treatment: systematic review and meta-analyses

Kleinrensink, Nienke J.; Pouw, Juliëtte N; Leijten, Emmerik F A; Takx, Richard A.P.; Welsing, Paco M J; Keizer, Bart de; Jong, Pim A. de; Foppen, Wouter

doi:10.1007/s40336-021-00476-3

Cited by 2 publications

(2 citation statements)

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“…Our observations are in line with previous work that has consistently showed increased vascular inflammation in Pso in comparison with the general population. [9][10][11][12][13][14] While currently limited data are available on vascular inflammation in PsA, increased…”

Section: Discussionmentioning

confidence: 99%

“…RMD Open RMD Open RMD Open controls, and skin severity is associated with aortic vascular inflammation. [9][10][11][12][13][14] The aim of this study is to investigate whether vascular inflammation measured by FDG PET/CT is elevated in PsA in comparison with patients without PsA. As a secondary outcome measure, we assessed whether the extent of clinical disease activity in PsA was associated with vascular inflammation.…”

Section: What This Study Addsmentioning

confidence: 99%

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Increased vascular inflammation on PET/CT in psoriatic arthritis patients in comparison with controls

Kleinrensink,

Spierings,

Vonkeman

et al. 2024

RMD Open

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BackgroundPatients with psoriatic arthritis (PsA) have an increased risk of cardiovascular disease, possibly due to a chronic inflammatory state.ObjectivesThe main objective of this study was to investigate the difference in vascular inflammation, measured with 18-fluorodeoxyglucose positron emission tomography/CT (PET/CT), in PsA patients and controls. We conducted a secondary analysis to assess the association between clinical parameters of disease activity with vascular inflammation in PsA.MethodsWe included a total of 75 PsA patients with active peripheral arthritis (defined as ≥2 tender and swollen joints) from an ongoing clinical trial (EudraCT 2017-003900-28) and a retrospective group of 40 controls diagnosed with melanoma, without distant metastases and not receiving immunotherapy. The main outcome measure was aortic vascular inflammation which was measured on PET/CT scans using target-to-background ratios. Clinical disease activity in PsA was assessed with joint counts, body surface area and the Disease Activity index for PsA. Laboratory assessments included C reactive protein and erythrocyte sedimentation rate.ResultsVascular inflammation was increased in patients with PsA in comparison with controls (mean target-to-background ratio for entire aorta, respectively, 1.63±0.17 vs 1.49±0.16; p=<0.001). This association remained significant after correction for gender, age, body mass index, mean arterial pressure and aortic calcification (p=0.002). Vascular inflammation was not associated with disease-related parameters.ConclusionsAortic vascular inflammation was significantly increased in patients with active PsA compared with controls. This evidence supports the theory that inflammation in PsA is not limited to the skin and joints but also involves the vascular system.

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Section: Discussionmentioning

confidence: 99%

Section: What This Study Addsmentioning

confidence: 99%

Increased vascular inflammation on PET/CT in psoriatic arthritis patients in comparison with controls

Kleinrensink,

Spierings,

Vonkeman

et al. 2024

RMD Open

Self Cite

View full text Add to dashboard Cite

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The Impact of Treatment with IL-17/IL-23 Inhibitors on Subclinical Atherosclerosis in Patients with Plaque Psoriasis and/or Psoriatic Arthritis: A Systematic Review

et al. 2023

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Accumulating evidence considers psoriasis a systemic inflammatory disorder that is associated with comorbidities such as psoriatic arthritis, cardiovascular disease, and metabolic syndrome. Although the precise pathogenetic links between psoriasis and atherosclerosis warrants further investigation, it is believed that chronic systemic inflammation along with the T helper (Th)-1 and Th17 polarization are associated with endothelial dysfunction and subsequent acceleration of atherosclerosis. Considering the above, several studies have evaluated if optimal control of the inflammation in psoriasis by inhibiting interleukins targeting the Interleukin (IL)-23/Th17 axis could subsequently reduce the atherosclerotic process during anti-psoriatic treatment by using a variety of surrogate markers of subclinical atherosclerosis. This systematic review summarizes current knowledge on the pathogenetic mechanisms and diagnostic evaluation of atherosclerosis in the context of psoriasis and provides a systematic review of the literature on the impact of treatment with biologics targeting the IL-23/Th17 axis on subclinical atherosclerosis in patients with plaque psoriasis and/or psoriatic arthritis.

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Increased vascular inflammation on PET/CT in psoriasis and the effects of biologic treatment: systematic review and meta-analyses

Cited by 2 publications

References 50 publications

Increased vascular inflammation on PET/CT in psoriatic arthritis patients in comparison with controls

Increased vascular inflammation on PET/CT in psoriatic arthritis patients in comparison with controls

The Impact of Treatment with IL-17/IL-23 Inhibitors on Subclinical Atherosclerosis in Patients with Plaque Psoriasis and/or Psoriatic Arthritis: A Systematic Review

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